The Aging Heart: Mitophagy at the Center of Rejuvenation

Frontiers in Cardiovascular Medicine
Wenjing J Liang, Åsa B Gustafsson

Abstract

Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular levels in various tissues, including the heart. It is known that there is an age-related decline in cellular quality control pathways such as autophagy and mitophagy, which leads to accumulation of potentially harmful cellular components in cardiac myocytes. There is evidence that diminished autophagy and mitophagy accelerate the aging process, while enhancement preserves cardiac homeostasis and extends life span. Here, we review the current knowledge of autophagy and mitophagy in aging and discuss how age-associated alterations in these processes contribute to cardiac aging and age-related cardiovascular diseases.

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Citations

May 26, 2020·EMBO Reports·Raz Bar-ZivAndrew Dillin
Sep 15, 2020·The Journal of Cell Biology·Samuel A KillackeyStephen E Girardin
Oct 6, 2020·Journal of Receptor and Signal Transduction Research·Jianguo BinYunjun Xu
Aug 24, 2020·Redox Biology·Nachiyappan VenkatachalamStanislav Engel
Jan 26, 2021·Frontiers in Neuroscience·Michael Tran, P Hemachandra Reddy
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Jeongha KimBuHyun Youn
Jul 27, 2021·Frontiers in Cardiovascular Medicine·Zhu Yuan, Weiqiang Huang
Aug 13, 2021·Stem Cell Research & Therapy·Qingyin LinYanzhou Yang

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Methods Mentioned

BETA
ubiquitination

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