The Aging Navigational System

Adam W LesterThomas Wolbers


The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and ...Continue Reading


Jul 8, 2018·Hippocampus·Stephen L CowenCarol A Barnes
Mar 31, 2019·British Journal of Psychology·Veronica MuffatoRossana De Beni
Sep 25, 2019·Journal of Clinical Medicine·Jessica Isbely MontanaGiuseppe Riva
Oct 23, 2019·Behavior Research Methods·Sean ComminsConor Thornberry
Sep 25, 2019·Nature Human Behaviour·Marcia BécuAngelo Arleo
Feb 19, 2020·Aging & Mental Health·Elena CarboneErika Borella
Jul 4, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yuri AgrawalLewis A Lipsitz
Jul 9, 2020·Human Brain Mapping·Laura ZapparoliEraldo Paulesu
Nov 6, 2018·Aging·Jan LaczóScott D Moffat
Sep 23, 2020·PloS One·Gillian CoughlanMichael Hornberger
Jul 26, 2018·Frontiers in Human Neuroscience·Jimmy Y Zhong, Scott D Moffat
Jun 28, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Antonella LopezAndrea Bosco
Mar 10, 2019·Psychological Research·Christopher HiltonJan Wiener
Apr 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Gillian CoughlanMichael Hornberger
Jun 25, 2019·Frontiers in Aging Neuroscience·Lee RyanCarol A Barnes
May 28, 2020·Nature Communications·Matthias StanglThomas Wolbers
Jul 8, 2018·Nature Reviews. Neurology·Gillian CoughlanMichael Hornberger
Aug 23, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Samantha Hughes, Tansu Celikel
Aug 9, 2019·Scientific Reports·Maayan Merhav, Thomas Wolbers
May 7, 2020·Frontiers in Human Neuroscience·Ellen LowryMichael Hornberger
Apr 17, 2020·Frontiers in Human Neuroscience·Gabriele JanzenRoy P C Kessels
Aug 29, 2020·Journal of Physiological Anthropology·Masafumi KunishigeChinami Ishizuki
Jan 13, 2018·Experimental Brain Research·Esther KuehnThomas Wolbers
Jul 19, 2018·Scientific Reports·Ismini E LokkaChristina Röcke
Dec 24, 2018·Frontiers in Behavioral Neuroscience·Nicanor Morales-DelgadoMiroljub Popović
Feb 8, 2019·The Journal of Experimental Biology·Nadine Diersch, Thomas Wolbers
Feb 13, 2020·Frontiers in Human Neuroscience·Veronica Muffato, Rossana De Beni
Dec 19, 2018·Learning & Memory·McKenna E WilliamsPaul E Gilbert
Nov 9, 2018·Frontiers in Aging Neuroscience·María Velasco-EstevezGraham K Sheridan
Apr 3, 2020·Aging & Mental Health·Ineke J M van der HamMichiel H G Claessen
Feb 26, 2020·Scientific Reports·Ineke J M van der HamMilan N A van der Kuil
Nov 19, 2019·Frontiers in Neural Circuits·Stephen RamanoëlAngelo Arleo
Dec 8, 2020·Frontiers in Aging Neuroscience·Catherine Persephone AgathosAngelo Arleo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

© 2021 Meta ULC. All rights reserved