The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and ...Continue Reading
The Mechanism of Cortico-Striato-Thalamo-Cortical Neurocircuitry in Response Inhibition and Emotional Responding in Attention Deficit Hyperactivity Disorder with Comorbid Disruptive Behavior Disorder
A novel real-space navigation paradigm reveals age- and gender-dependent changes of navigational strategies and hippocampal activation
The role of visuo-spatial abilities in environment learning from maps and navigation over the adult lifespan
Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation.
The orientation of young and older adults' mental representations of their home town with familiar and new landmarks.
Anterior and posterior hippocampus macro- and microstructure across the lifespan in relation to memory-A longitudinal study.
Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
Using the Walking Corsi test to explain age-related differences between young and older adults' rotation performance.
Aging, Vestibular Function, and Balance: Proceedings of a National Institute on Aging/National Institute on Deafness and Other Communication Disorders Workshop.
A pilot study evaluating the effects of concussion on the ability to form cognitive maps for spatial orientation in adolescent hockey players.
Spatial navigation ability is associated with the assessment of smoothness of driving during changing lanes in older drivers
Path Learning From Navigation in Aging: The Role of Cognitive Functioning and Wayfinding Inclinations
Testing Navigation in Real Space: Contributions to Understanding the Physiology and Pathology of Human Navigation Control.
Differences in Encoding Strategy as a Potential Explanation for Age-Related Decline in Place Recognition Ability
Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes
Age-related differences in visual encoding and response strategies contribute to spatial memory deficits.
A bedside application-based assessment of spatial orientation and memory: approaches and lessons learned
A novel virtual-reality-based route-learning test suite: Assessing the effects of cognitive aging on navigation
From repeating routes to planning novel routes: the impact of landmarks and ageing on route integration and cognitive mapping.
Age-Related Differences in Functional and Structural Connectivity in the Spatial Navigation Brain Network
Differential Brain Activity in Regions Linked to Visuospatial Processing During Landmark-Based Navigation in Young and Healthy Older Adults
Postural Control While Walking Interferes With Spatial Learning in Older Adults Navigating in a Real Environment
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Brain developing: Influences & Outcomes
This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.