PMID: 28501840Jan 1, 2015Paper

The aging of the immune system

Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Magdalena PierzynaBogdan Mazur

Abstract

The age-related deterioration of health condition associated with progressive impairment of innate and adaptive immunity was defined as the aging of the immune system (also known as immunosenescence). Many changes occur within the immune system with age, including in particular quantitative changes in populations and subpopulations of cells resulting in dysfunction of the immune system. Elderly patients often have chronic systemic low grade inflammation process which is an effect of the inflammatory mediators secretion. Changes in the levels of mediators have a negative impact on coexisting disease and body's ability to fight infections. The purpose of the paper is to characterize the changes in proportions and functions of immune cells during the aging.

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