The aging/precancerous gastric mucosa: a pilot nutraceutical trial

Annals of the New York Academy of Sciences
F MarottaE Fesce

Abstract

The aim of this study was to test the effect of antioxidant supplementation on enzymatic abnormalities and free radical-modified DNA adducts associated with premalignant changes in the gastric mucosa of elderly patients with HP-negative atrophic gastritis (CAG). Sixty patients with atrophic gastritis and intestinal metaplasia underwent a nutritional interview and a gastroscopy with multiple biopsy samples in the antrum that were processed for histology and for assaying: alpha-tocopherol, MDA, xanthine oxidase (XO), ornithine decarboxylase (ODC), and 8-OHdG. Patients were randomly allocated into three matched groups and supplemented for 6 months with (1) vitamin E, 300 mg/day; (2) multivitamin, two tablets t.i.d.; and (3) Immun-Age 6 g/day nocte (ORI, Gifu, Japan), a certified fermented papaya preparation with basic science-validated antioxidant/immunomodulant properties. Ten dyspeptic patients served as controls. Histology and biochemistry were blindly repeated at 3 and 6 months. CAG patients showed a significantly (P <.05) increased level of mucosal MDA and XO concentration that were reverted to normal by each supplementation (P <.05). All supplements caused a significant decrease of ODC (P <.01), but Immun-Age yielded the mos...Continue Reading

References

Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
Jul 1, 1993·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·G P XuP I Reed
Jun 1, 1996·Scandinavian Journal of Gastroenterology·J ValleM Siurala

❮ Previous
Next ❯

Citations

Apr 29, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Okezie I AruomaTheeshan Bahorun
Apr 21, 2007·Journal of Gastroenterology and Hepatology·Francesco MarottaLester Packer
Dec 10, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jhoti SomanahOkezie I Aruoma
Aug 5, 2008·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Nov 19, 2010·Expert Review of Hematology·Sara T Olalla-Saad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.