PMID: 1440473Sep 1, 1992

The airway microvasculature and exercise induced asthma

Thorax
S D Anderson, E Daviskas

Abstract

It has been proposed that exercise induced asthma is a result of "rapid expansion of the blood volume of peribronchial plexi" (McFadden ER, Lancet 1990;335:880-3). This hypothesis proposes that the development of exercise induced asthma depends on the thermal gradient in the airways at the end of hyperpnoea. The events that result in exercise induced asthma are vasoconstriction and airway cooling followed by reactive hyperaemia. We agree that the airway microcirculation has the potential for contributing to the pathophysiology of exercise induced asthma. We do, however, question whether reactive hyperaemia, in response to airway cooling, is the mechanism whereby hyperpnoea provokes airways obstruction in asthmatic patients. Further, we question whether vasoconstriction accompanies dry air breathing and whether an abnormal temperature gradient and rapid rewarming of the airways are prerequisites for exercise induced asthma. From published experiments we conclude that dry air breathing is associated with vasodilation and increase in airway blood flow rather than vasoconstriction and a decrease in blood flow to the airways. We propose that the stimulus for the increase in airway blood flow is an increase in osmolarity of the airwa...Continue Reading

References

Sep 1, 1995·Pediatric Pulmonology·W B HofstraE J Duiverman
Oct 23, 2008·Current Allergy and Asthma Reports·Terrence W Carver
Jul 11, 2012·Current Allergy and Asthma Reports·Regina R PillaiWilliam J Calhoun
Sep 26, 2002·Paediatric Respiratory Reviews·Kai-Håkon Carlsen, Karin C L Carlsen
Jun 29, 2001·Clinical and Experimental Pharmacology & Physiology·S W WhiteD B Cottee
Jul 8, 1993·The New England Journal of Medicine·T AhmedI Danta
Jan 2, 1997·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·S D Anderson
Sep 1, 1994·European Journal of Clinical Investigation·H K Makker, S T Holgate
May 1, 1997·Allergy·A M Campbell
Jan 27, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·K-H Carlsen
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·John D BrannanN Chew
Aug 7, 2010·Medicine and Science in Sports and Exercise·Katrin StadelmannKai-Haakon Carlsen
Jan 22, 2005·Treatments in Respiratory Medicine·S D Anderson
May 6, 2004·Current Opinion in Allergy and Clinical Immunology·Henry Milgrom
Jul 9, 2013·Immunology and Allergy Clinics of North America·S Godfrey, Kenneth D Fitch
Jul 9, 2013·Immunology and Allergy Clinics of North America·Pascale Kippelen, S D Anderson
Apr 4, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Timothy J Craig, Melanie C Dispenza
Jan 5, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·John M WeilerJoint Council of Allergy, Asthma and Immunology
Jun 17, 2008·The Journal of Allergy and Clinical Immunology·S D Anderson, Pascale Kippelen
Jun 24, 2006·Journal of Pharmacological and Toxicological Methods·Jeffrey S FedanMichael R Van Scott
Dec 1, 1995·The Journal of Allergy and Clinical Immunology·F SouquesA M Campbell
Aug 20, 2003·Respiratory Medicine·E D MoloneyS O'Sullivan
Jul 1, 1993·Respiratory Medicine·S Godfrey, E Bar-Yishay
Sep 26, 2016·The Journal of Allergy and Clinical Immunology·John M WeilerDana Wallace
Feb 26, 2016·European Clinical Respiratory Journal·S D Anderson
Mar 5, 2008·Allergy·K-H Carlsen, M L Kowalski
Sep 1, 1996·Respirology : Official Journal of the Asian Pacific Society of Respirology·S D Anderson
Aug 9, 2019·Pediatric Pulmonology·Anna P TikkakoskiLauri Lehtimäki
Jan 18, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A PanaritiQ Hamid
Apr 1, 1996·Medicine and Science in Sports and Exercise·P A Nixon
Aug 1, 2002·Drugs·Robert W Gotshall
May 9, 2003·Journal of Applied Physiology·Michael S DavisS D Anderson
Apr 2, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Young Yull KohChang Keun Kim
Feb 5, 2000·Journal of Applied Physiology·M P Zimmerman, T E Pisarri

Citations

Mar 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E C DealJ J Jaeger
Oct 20, 1975·JAMA : the Journal of the American Medical Association·C W BiermanG G Shapiro
Oct 1, 1991·Journal of Applied Physiology·D R CorfieldJ G Widdicombe
Apr 1, 1991·Respiration Physiology·E DaviskasS D Anderson
Aug 1, 1991·The American Review of Respiratory Disease·A N FreedC E Stream
Jun 1, 1991·Journal of Applied Physiology·H NoseT Morimoto
Jul 1, 1991·Journal of Applied Physiology·R O SalonenJ G Widdicombe
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C G PerssonC Svensson
Jun 1, 1990·The American Review of Respiratory Disease·M E CseteA Wanner
Nov 1, 1990·The American Review of Respiratory Disease·S P BlackieP D Paré
Oct 1, 1990·The American Review of Respiratory Disease·I A GilbertE R McFadden
Jul 1, 1990·Journal of Applied Physiology·E DaviskasS D Anderson
Nov 1, 1989·The Journal of Allergy and Clinical Immunology·C M Smith, S D Anderson
Mar 1, 1989·Journal of Applied Physiology·M E DeffebachJ G Widdicombe
Mar 1, 1989·Journal of Applied Physiology·G H ParsonsE M Baile
May 1, 1989·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·S D AndersonC M Smith
May 1, 1988·New England and Regional Allergy Proceedings·N G BelcherT H Lee
Jun 1, 1987·Journal of Applied Physiology·J R YankaskasR C Boucher
Dec 1, 1988·The American Review of Respiratory Disease·D K ZawadskiE R McFadden
Feb 1, 1987·Journal of Applied Physiology·E M BaileP D Paré
Oct 1, 1987·Journal of Applied Physiology·I A GilbertE R McFadden
Jul 1, 1985·Journal of Applied Physiology·W M LongA Wanner
Sep 1, 1972·Anesthesiology·J ChalonJ Malebranche
Dec 1, 1972·Archives of Disease in Childhood·M Silverman, S D Anderson
Nov 1, 1982·The British Journal of Dermatology·G S BasranM Turner-Warwick
May 1, 1984·The Journal of Allergy and Clinical Immunology·S D Anderson
Jan 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·V A ConvertinoJ E Greenleaf
Jul 1, 1990·Archives of Gerontology and Geriatrics·G PaolissoF D'Onofrio

Related Concepts

Microvascular Network
Asthma, Exercise-Induced
Bronchial System
Bronchospasm, Exercise-Induced
Reactive Hyperemia
Entire Lumen of Body System
Cold Temperature
Pathologic Vasoconstriction
Airway Resistance
Osmolarity Measurement

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