Abstract
The Akt/mTOR pathway is activated in many malignancies, including oral squamous cell carcinoma (OSCC). However, the role of the Akt/mTOR pathway in oral verrucous carcinoma (OVC), a low-grade variant of OSCC, remains unknown. Thus, the objective of this study was to investigate the activation level of important markers of the Akt/mTOR pathway in OVC and to compare the results with OSCC samples. The expression of p-Akt (Thr308), p-Akt (Ser473), and p-RPS6 was evaluated by immunohistochemistry in 30 OSCC cases, 18 OVC cases, and 30 control cases (normal epithelium overlying fibromas). Statistical analysis was performed to determine the differences in protein expression between samples. All OVC cases were positive for p-Akt (Thr308), p-Akt (Ser473), and p-RPS6. There were significant differences in expression level of all studied proteins between OVC and control, as well as between OVC and OSCC. However, OVC showed significant lower staining scores than OSCC. Our findings demonstrate that the Akt/mTOR pathway is upregulated in OVC, indicating a role for this pathway in the development and progression of this malignancy.
References
Jul 1, 1994·Archives of Otolaryngology--head & Neck Surgery·J A AndersonB Y Ngan
Mar 4, 2000·The Biochemical Journal·B Vanhaesebroeck, D R Alessi
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
May 4, 2004·Nature Reviews. Cancer·Mary-Ann Bjornsti, Peter J Houghton
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Jun 2, 2006·Clinical Oral Investigations·Denise Tostes OliveiraLuiz Paulo Kowalski
Jul 7, 2007·Cancer Cell·David A Guertin, David M Sabatini
Jul 16, 2008·Oral Oncology·Rohan R WalvekarAnil K D'Cruz
Sep 23, 2008·Oral Oncology·Alfredo A MolinoloJ Silvio Gutkind
Apr 17, 2010·Oral and Maxillofacial Surgery·K P Rekha, Punnya V Angadi
Nov 30, 2010·Expert Opinion on Therapeutic Targets·Christian FreudlspergerCarter Van Waes
Apr 21, 2011·British Journal of Cancer·E E VincentJ M Tavaré
Jun 2, 2012·Journal of Maxillofacial and Oral Surgery·Tadashi Terada
Jan 1, 2011·BMJ Case Reports·Jay Gopal RayKeya Chaudhuri
Jun 29, 2012·Oncology Letters·Hongzhi QuanJun Zuo
Sep 28, 2012·Pathology Oncology Research : POR·Risa ChaisuparatSomchai Yodsanga
Apr 20, 2013·Cancer Letters·Avaniyapuram Kannan MuruganNobuo Tsuchida
Aug 21, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Risa ChaisuparatBruno C Jham
Jun 2, 2014·Medicina oral, patología oral y cirugía bucal·Alberto Candau-AlvarezBorja Valenzuela-Salas
May 28, 2015·International Journal of Cancer. Journal International Du Cancer·Manar SammanPamela Rabbitts
Citations
Nov 4, 2016·Oral Diseases·N G Nikitakis
May 8, 2019·Environmental Toxicology·Cheng-Wen LinJing-Ru Weng
Apr 29, 2016·International Journal of Oncology·Qian PengZhangui Tang
Sep 21, 2019·Technology in Cancer Research & Treatment·Li Q ZhangLing P Zhao
May 10, 2020·International Journal of Molecular Sciences·Choudhary HarshaAjaikumar B Kunnumakkara
Aug 7, 2021·Frontiers in Pharmacology·Nikita AggarwalAlok Chandra Bharti