The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission

EMBO Reports
Hazem SaforyHerman Wolosker

Abstract

Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transporter, and its transport activity is required for the subsequent conversion of L-serine into glycine in vivo. Asc-1 is a novel regulator of glycine metabolism and a candidate for hyperekplexia disorders.

References

May 25, 1991·European Journal of Pharmacology·H ChristensenF Fonnum
Jul 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C M Becker
Oct 1, 1970·Journal of Neurochemistry·R P Shank, M H Aprison
Mar 29, 2000·Journal of Neurochemistry·X F Wang, M S Cynader
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Nov 19, 2003·The European Journal of Neuroscience·Lone HelboeChristian Thomsen
May 6, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin K YeeJoram Feldon
Aug 4, 2006·Biochemical and Biophysical Research Communications·Volker EulenburgHeinrich Betz
Aug 19, 2008·Trends in Genetics : TIG·Robert J HarveyMark I Rees
Oct 18, 2008·Nature Protocols·Peter R DunkleyPhillip J Robinson
Apr 8, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dina RosenbergHerman Wolosker
May 8, 2010·Molecular and Cellular Neurosciences·A Tobias LatalSwen Hülsmann
Oct 18, 2011·Journal of Inherited Metabolic Disease·Julia B HennermannJohan L K Van Hove
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dina RosenbergHerman Wolosker
May 24, 2013·The Journal of Nutrition·Elena V AbarinovPatrick J Stover
Nov 22, 2013·Biochemical Society Transactions·Herman Wolosker, Inna Radzishevsky
Dec 24, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nobuhiro KawaiSeiji Nishino

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Citations

Jun 20, 2015·Journal of Neurochemistry·Jean-Pierre MothetJean-Marie Billard
Jan 30, 2018·Frontiers in Molecular Neuroscience·Anja ArmbrusterVolker Eulenburg
Aug 18, 2018·Expert Opinion on Drug Metabolism & Toxicology·Qianwen Wang, Zhong Zuo
Sep 10, 2019·Nucleic Acids Research·Jiayi YinFeng Zhu
Jun 16, 2016·Journal of Neuroscience Research·Katsuya SakimuraHaruhide Kimura
Dec 22, 2016·Neuronal Signaling·Francisco ZafraCecilio Giménez
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Samah NeameHerman Wolosker
Feb 20, 2021·Neurochemical Research·Ekaitz Errasti-Murugarren, Manuel Palacín
Feb 27, 2021·Frontiers in Synaptic Neuroscience·Sina E BrillEckhard Friauf
Mar 13, 2021·Nature Communications·Lisa SuwandhiSiegfried Ussar
Jul 25, 2021·International Journal of Molecular Sciences·Mark W SherwoodAude Panatier
Mar 2, 2019·ACS Chemical Neuroscience·Ivan R TorrecillasGary Tresadern

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