The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa

The Journal of Biological Chemistry
Mami KurosakiEnrico Garattini

Abstract

Mammalian molybdo-flavoenzymes are oxidases requiring FAD and molybdopterin (molybdenum cofactor) for their catalytic activity. This family of proteins was thought to consist of four members, xanthine oxidoreductase, aldehyde oxidase 1 (AOX1), and the aldehyde oxidase homologues 1 and 2 (AOH1 and AOH2, respectively). Whereas the first two enzymes are present in humans and various other mammalian species, the last two proteins have been described only in mice. Here, we report on the identification, in both mice and rats, of a novel molybdo-flavoenzyme, AOH3. In addition, we have cloned the cDNAs coding for rat AOH1 and AOH2, demonstrating that this animal species has the same complement of molybdo-flavoproteins as the mouse. The AOH3 cDNA is characterized by remarkable similarity to AOX1, AOH1, AOH2, and xanthine oxidoreductase cDNAs. Mouse AOH3 is selectively expressed in Bowman's glands of the olfactory mucosa, although small amounts of the corresponding mRNA are present also in the skin. In the former location, two alternatively spliced forms of the AOH3 transcript with different 3'-untranslated regions were identified. The general properties of AOH3 were determined by purification of mouse AOH3 from the olfactory mucosa. The...Continue Reading

References

Jun 15, 1990·The Biochemical Journal·S Shaw, E Jayatilleke
Jan 1, 1981·Hormone Research·S M Ventura, S L Dachtler
Feb 10, 1995·The Journal of Biological Chemistry·A SatoT Nishino
Jan 1, 1995·Cytogenetics and Cell Genetics·E M RytkönenK O Raivio
Mar 15, 1994·Biochemical and Biophysical Research Communications·P XuJ R Hoidal
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R M WrightJ E Repine
Dec 27, 1993·FEBS Letters·S TomitaY Ichikawa
Dec 29, 1995·The Journal of Biological Chemistry·M L CalziE Garattini
Apr 1, 1996·The Biochemical Journal·M Saksela, K O Raivio
Feb 1, 1997·Archives of Biochemistry and Biophysics·S Yoshihara, K Tatsumi
Aug 1, 1997·Biochemical Society Transactions·M TeraoE Garattini
Oct 24, 1998·The Journal of Comparative Neurology·J M HuardJ E Schwob
Nov 24, 1999·The Journal of Biological Chemistry·W AmbroziakR Pietruszko
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·C EnrothE F Pai
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M SeoT Koshiba
Apr 20, 2001·The Journal of Veterinary Medical Science·S TsuchidaM Tagawa
Oct 23, 2001·Advances in Protein Chemistry·H SchindelinK V Rajagopalan
Jul 31, 2002·Journal of Experimental Botany·Ralf R Mendel, Robert Hänsch
Sep 5, 2002·Free Radical Biology & Medicine·Roger Harrison
Nov 7, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B G LakeJ A Scatina
Dec 5, 2002·Archives of Biochemistry and Biophysics·Frank J Gonzalez, Shioko Kimura
Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elena PirasEva B Brittebo
Mar 6, 2004·Pharmacological Reviews·Martijn RooseboomNico P E Vermeulen
Jul 9, 2004·Drug Metabolism Reviews·Roger Harrison

❮ Previous
Next ❯

Citations

Feb 20, 2010·European Journal of Drug Metabolism and Pharmacokinetics·Ping LiuRui-Chen Guo
Sep 29, 2012·The Journal of Biological Chemistry·Catarina CoelhoMaria João Romão
Feb 3, 2009·Biological & Pharmaceutical Bulletin·Kunio ItohYorihisa Tanaka
Dec 25, 2012·Cellular and Molecular Life Sciences : CMLS·Mami KurosakiEnrico Garattini
Feb 18, 2012·Expert Opinion on Drug Metabolism & Toxicology·Enrico Garattini, Mineko Terao
Mar 25, 2011·Drug Metabolism Reviews·Enrico Garattini, Mineko Terao
Apr 10, 2013·Expert Opinion on Drug Discovery·Enrico Garattini, Mineko Terao
Jan 14, 2010·Drug Metabolism Reviews·Jean-Marie HeydelAnne-Marie Le Bon
Feb 28, 2016·Archives of Toxicology·Mineko TeraoEnrico Garattini
May 17, 2006·Drug Metabolism and Pharmacokinetics·Shigeyuki KitamuraShigeru Ohta
Oct 8, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Nuno M F S A CerqueiraMaria João Ramos
Jul 28, 2016·Scientific Reports·Mineko TeraoEnrico Garattini
Mar 22, 2007·Clinical Pharmacology and Therapeutics·Y TayamaK Kihira
Jan 21, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Peiqiang MuYiqun Deng
Mar 8, 2020·The Journal of Biological Chemistry·Mineko TeraoSilke Leimkühler
May 5, 2006·The Journal of Biological Chemistry·Mineko TeraoEnrico Garattini
Dec 30, 2009·Human Genomics·Enrico GarattiniMineko Terao
Aug 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jean-Marie HeydelLoïc Briand
Sep 2, 2017·Scientific Reports·Masashi AsakawaMasafumi Yohda
Nov 22, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kazumi SugiharaShigeyuki Kitamura
Jan 30, 2021·The Journal of Biological Chemistry·Mineko TeraoSilke Leimkühler
May 18, 2005·Biochemical and Biophysical Research Communications·C MerlinM Maïbèche-Coisne
Jun 21, 2006·Biochimica Et Biophysica Acta·Ralf R Mendel, Florian Bittner
Aug 7, 2019·Journal of Medicinal Chemistry·Nenad ManevskiFrancesca Toselli
Apr 26, 2011·Coordination Chemistry Reviews·Russ HilleFlorian Bittner

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.