The ALDH2 and 5-HT2A genes interacted in bipolar-I but not bipolar-II disorder

Progress in Neuro-psychopharmacology & Biological Psychiatry
Sheng-Yu LeeRu-Band Lu

Abstract

Clarifying the similarities and differences between the two most common subtypes of bipolar disorder, bipolar-I and bipolar-II, is essential for improving our understanding of them. Because the serotonergic system has been implicated in the pathogenesis of bipolar disorder, it may be important to investigate genes such as the aldehyde dehydrogenase 2 (ALDH2) and serotonin 2A receptor genes, which are involved in metabolizing serotonin and encoding serotonin receptors. We examined the association of the ALDH2 and 5-HT2A-A1438G polymorphisms with bipolar I and II and possible interactions between these genes. One thousand forty-nine participants were recruited: 249 with bipolar-I, 456 with bipolar-II, and 344 healthy controls. The genotypes of the ALDH2 and 5HT2A-A1438G polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Logistic regression analysis showed a significant effect of the ALDH2 and the 5-HT2A-A1438G polymorphisms, and a significant interaction effect for the A/G genotypes of the 5-HT2A-A1438G polymorphism and the ALDH2*1*1 genotypes (p=0.004) discriminated between bipolar-I patients and controls without bipolar disorder. These polymorphisms, however, w...Continue Reading

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Citations

Jan 23, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jinjing TanLian Gu
Jun 17, 2014·Alcoholism, Clinical and Experimental Research·Akiko MatsumotoMasayoshi Ichiba
Apr 29, 2014·Journal of Affective Disorders·Zuowei WangYiru Fang
Feb 3, 2016·Nihon eiseigaku zasshi. Japanese journal of hygiene·Akiko Matsumoto
Aug 6, 2017·The Australian and New Zealand Journal of Psychiatry·Sheng-Yu LeeRu-Band Lu
Feb 2, 2018·Nihon eiseigaku zasshi. Japanese journal of hygiene·Akiko Matsumoto
Aug 7, 2020·Neuroscience and Biobehavioral Reviews·Hugo Sérgio AlmeidaAntonio Benabarre
May 23, 2014·ACS Chemical Neuroscience·Hong RenJacob M Hooker

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