The aldosterone receptor--new insights?

Expert Opinion on Investigational Drugs
Peter J Fuller

Abstract

Aldosterone, or mineralocorticoid, excess plays an important role in the pathophysiology of cardiac disease. This response is mediated through the mineralocorticoid receptor (MR). Although blockade of the MR has been shown to reduce mortality in cardiac failure, therapy may be limited by the hyperkalaemia that results from blockade of the renal MR. It is now well established for a number of steroid receptors that tissue-specific antagonism and agonism can be achieved by the so-called selective receptor modulators. Recently, three groups have crystallised the ligand-binding pocket of the MR, and each reveal a structure that is similar to that of the other steroid receptors. This raises the possibility that cardiac-specific antagonists of the MR may be developed that avoid the potassium retention seen with blockade of the renal MR.

References

Apr 28, 2004·Trends in Endocrinology and Metabolism : TEM·John W Funder
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·D G LevyJ W Funder
Aug 6, 2004·The New England Journal of Medicine·David N JuurlinkDonald A Redelmeier
May 24, 2005·Nature Structural & Molecular Biology·Jérôme FagartMarie-Edith Rafestin-Oblin
Jun 22, 2005·The Journal of Biological Chemistry·Randy K BledsoeShawn P Williams
Sep 1, 2005·The Journal of Biological Chemistry·Casey E BohlJames T Dalton
Nov 16, 2005·Hypertension·Peter J Fuller, Morag J Young
Nov 26, 2005·Expert Opinion on Investigational Drugs·Jeffrey N MinerAndrés Negro-Vilar

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Citations

Jul 21, 2011·Molecular and Cellular Endocrinology·Peter Kolkhof, Steffen A Borden
Jul 18, 2015·Sociology of Health & Illness·Simon J WilliamsRobert Meadows

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