PMID: 2496684Feb 1, 1989Paper

The aldox-2 locus of Drosophila melanogaster also affects sulfite oxidase and molybdenum metabolism

Biochemical Genetics
M M BentleyA C Braaten

Abstract

Mutation at the aldox-2 locus in Drosophila melanogaster affects the specific activities of four molybdoenzymes differentially during development. Sulfite oxidase activity is normal during late larval and pupal stages but is reduced during early adult stages in aldox-2 organisms. There was complete concordance among the effects of aldox-2 on sulfite oxidase, aldehyde oxidase, xanthine dehydrogenase, and pyridoxal oxidase, when 38 stocks were analyzed which were derived from single recombination events between c and px, markers which flank aldox-2. Several different biochemical analyses indicate that the active molybdoenzymes present in the aldox-2 strain are normal with respect to size, shape, pH-activity profile, Km, and molecular weight. Significant differences were found between the aldox-2 strain and the OR control strain in their responses to dietary Na2MoO4 and Na2WO4. The mutant strain is much more resistant to the effects of dietary Na2WO4 and much more responsive to the administration of Na2MoO4 than the OR control strain when these effects are quantitated by measurements of molybdoenzyme specific activities. This evidence suggests that the aldox-2+ gene product has a molybdenum binding site which can also bind tungste...Continue Reading

References

Dec 1, 1978·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·J H WilliamsonB W Geer
Jan 1, 1978·Cold Spring Harbor Symposia on Quantitative Biology·A ChovnickS Clark
Oct 1, 1986·Biochemical Genetics·R G Meidinger, M M Bentley
Sep 1, 1967·Genetics·J B Courtright
Jan 1, 1981·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·M M BentleyM J Oliver
Jan 1, 1982·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·M M Bentley, J H Williamson
Jan 1, 1982·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·M M Bentley, J H Williamson

❮ Previous
Next ❯

Citations

Oct 1, 1993·Biochemical Genetics·A C Braaten, M M Bentley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.