The alerting effect of the wake maintenance zone during 40 hours of sleep deprivation

Scientific Reports
Jan de ZeeuwMirjam Münch

Abstract

Under entrained conditions, the accumulation of homeostatic sleep pressure in the evening is opposed by a strong circadian arousal signal prior to the dim light melatonin onset, called the Wake Maintenance Zone (WMZ). This study aimed at investigating the impact of the WMZ on different cognitive performance tests, as well as on subjective and objective sleepiness. Twelve young male participants completed a constant routine protocol with 40 h of extended wakefulness that included two WMZs. Cognitive tests and saliva samples were assessed hourly, while the electroencephalogram (EEG) was recorded continuously. Participants improved in cognitive response inhibition during WMZ1 (13.5 h awake) and sustained attention during WMZ2 (37.5 h awake), but not in higher executive function tests. There were significant EEG power density reductions in the delta/theta frequency range during WMZ1 and in delta/theta, alpha, and sigma/beta ranges during WMZ2, with a greater change in the sigma/beta range during WMZ2 compared to WMZ1. EEG power reductions coincided during WMZ1 with stable subjective sleepiness and sustained attention. During WMZ2, EEG power reductions were more pronounced and coincided with improved sustained attention. Our results...Continue Reading

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Citations

Mar 8, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Aljohara S AlmeneessierAhmed S BaHammam
Jul 25, 2019·Biology·Till RoennebergEva C Winnebeck
Jan 21, 2021·Cognitive, Affective & Behavioral Neuroscience·Annika DimitrovIlya M Veer
Jan 23, 2021·Journal of the American College of Radiology : JACR·Abdulaziz S AlshabibiPatrick C Brennan
Apr 6, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mehmet Karadag, Gulay Can Yilmaz
Jun 8, 2021·Seminars in Cell & Developmental Biology·Raymond E A SanchezHoracio O de la Iglesia
Oct 14, 2021·Aerospace Medicine and Human Performance·Marion Venus, Martin Grosse Holtforth

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