PMID: 2493441Mar 1, 1989Paper

The algR gene, which regulates mucoidy in Pseudomonas aeruginosa, belongs to a class of environmentally responsive genes

Journal of Bacteriology
V DereticT K Misra

Abstract

The Pseudomonas aeruginosa capsule, composed of polysaccharide alginate, is an important Pseudomonas virulence factor encountered primarily in cystic fibrosis. The regulatory algR gene positively controls transcription of a key alginate biosynthetic gene, algD. The algR gene was subcloned and sequenced by creating a set of nested deletions in M13 bacteriophage. DNA sequence analysis of algR revealed the homology of its gene product with a recently recognized class of environmentally responsive bacterial regulatory genes, including ompR, phoB, sfrA, ntrC, spoOA, dctD, and virG; these transcriptional activators control cellular reactions to osmotic pressure, phosphate limitations, or specific chemical compounds present in the medium or released from wounded host tissue. These findings indicate that novel conditions in lungs affected by cystic fibrosis may be participating in the control of mucoidy.

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Citations

Nov 1, 1989·Molecular Microbiology·R GrossR Rappuoli
Feb 27, 2009·FEMS Microbiology Reviews·W James Gooderham, Robert E W Hancock
Oct 8, 2013·Journal of Bacteriology·Yuta OkkotsuMichael J Schurr
Jul 8, 2014·Frontiers in Cellular and Infection Microbiology·Yuta OkkotsuMichael J Schurr
May 13, 2014·Journal of Bacteriology·Chie HayashiWataru Hashimoto
Dec 10, 2014·Journal of Bacteriology·Christopher L PritchettMichael J Schurr
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Jan 1, 1993·Journal of Cellular Biochemistry·A J Cozzone
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Aug 4, 2004·Microbiology·Alejandro Peñaloza-VázquezCarol L Bender
Feb 26, 2020·Infection and Immunity·Mihnea R Mangalea, Breck A Duerkop
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Jul 1, 1993·World Journal of Microbiology & Biotechnology·J L Ramos, S Marqués
Jan 4, 2012·FEMS Microbiology Reviews·Ethan E Mann, Daniel J Wozniak
May 28, 2020·Journal of Medical Microbiology·Divakar BadalVarsha Singh
Oct 16, 2002·Infection and Immunity·Stephen E LizewskiMichael J Schurr

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