The alien limb phenomenon and Creutzfeldt-Jakob disease

Parkinsonism & Related Disorders
Mark RubinAllen J Aksamit

Abstract

Alien limb phenomenon (ALP) has been rarely reported as a presenting feature of Creutzfeldt-Jakob disease (CJD), though neurologists may not recognize it as a prompt to search for CJD. This report demonstrates the clinical features of patients with ALP and CJD. All patients with the ALP between 1/1/1996 - 7/28/2011 were identified by the Mayo Clinic Medical Record Linkage system and cross-referenced with a diagnosis of CJD in that same time span. This yielded 13 patients, including six women. The median age at onset of CJD symptoms was 69 years. Two patients were classified as possible CJD, five as probable CJD, and six as definite CJD based on research diagnostic criteria for CJD. The median time to onset of ALP symptoms was 0.5 weeks. The ALP afflicted the left side in nine patients. The median time to death from CJD symptom onset was 10.5 weeks. In four patients ALP was the initial and sole neurologic sign. In four others it was the initial manifestation coexisting with other deficits. ALP related symptoms initially prompted three other patients to seek medical evaluation. ALP was either initially or eventually accompanied by ipsilateral hemineglect, ideomotor apraxia and/or cortical sensory loss in nine patients. Imaging of...Continue Reading

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Citations

Apr 11, 2013·Journal of Neurology·Jonathan Graff-RadfordKeith A Josephs
Oct 25, 2014·Rinshō shinkeigaku = Clinical neurology·Kenji KamogawaBungo Okuda
Dec 18, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Valentina ArnaoPaolo Aridon
Oct 3, 2012·Parkinsonism & Related Disorders·Mark N Rubin
Nov 28, 2012·Parkinsonism & Related Disorders·Silvana ZanninoAndrea Romigi
Jun 18, 2016·Current Neurology and Neuroscience Reports·Anhar Hassan, Keith A Josephs
Jul 17, 2018·Journal of Alzheimer's Disease : JAD·Simone BaiardiPiero Parchi
May 10, 2017·Frontiers in Human Neuroscience·Arantxa AlfaroEduardo Fernández
Oct 5, 2016·Experimental and Therapeutic Medicine·Xiaoyu GaoChunjuan Sun
May 14, 2021·Movement Disorders Clinical Practice·Jasper Broekmeulen, Sam Thissen

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