The allantoin and uracil permease gene sequences of Saccharomyces cerevisiae are nearly identical

Yeast
H S YooT G Cooper

Abstract

We have determined the structure of the allantoin permease (DAL4) gene of Saccharomyces cerevisiae. The gene putatively encodes a hydrophobic protein with a M(r) of 71,755. It possesses the alternating hydrophobic-hydrophilic regions similar to those found in many other integral membrane proteins. The most striking feature of the allantoin permease component encoded by DAL4 is its striking similarity to the uracil permease component encoded by FUR4. Although data available indicate that these proteins do not share any overlap of function, their predicted protein sequences are 68% identical, 81% similar, and their DNA sequences are 70% identical. The upstream regulatory region of DAL4 contains all of the characterized cis-acting elements previously reported for inducible allantoin pathway genes: six sequences homologous to UASNTR, the element responsible for nitrogen catabolite repression-sensitive activation of allantoin pathway gene expression, and two sequences homologous to the cis-acting element responsible for inducer-responsiveness of the allantoin pathway genes, UIS. The finding of these homologous sequences predicted to exist on the basis of DAL4's expression characteristics, supports and strengthens the suggestion that...Continue Reading

References

Sep 1, 1977·Journal of Bacteriology·R Sumrada, Terrance G Cooper
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Aug 1, 1978·Journal of Bacteriology·R SumradaTerrance G Cooper
Dec 1, 1991·Yeast·R G Buckholz, T G Cooper
Aug 1, 1989·Journal of Bacteriology·K SzkutnickaV P Cirillo
Nov 1, 1986·Molecular and Cellular Biology·F S Genbauffe, T G Cooper
Jan 15, 1988·European Journal of Biochemistry·R JundM R Chevallier
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Citations

Aug 11, 1993·Nucleic Acids Research·R A Dorrington, T G Cooper
Apr 20, 2006·Journal of Bacteriology·Shun'ichi Suzuki, Peter J F Henderson
Mar 16, 2012·Genetics·Per O Ljungdahl, Bertrand Daignan-Fornier
Feb 26, 2015·Molecular Microbiology·Emilia KrypotouG Diallinas
Feb 9, 2008·The Journal of Biological Chemistry·Peter A BelenkyCharles Brenner
Aug 1, 1997·The Journal of Biological Chemistry·F EnjoH Nishimura
Aug 17, 2004·The Journal of Biological Chemistry·Anja SchmidtMarcelo Desimone
Jan 7, 1998·Molecular and Cellular Biology·C MarchalD Urban-Grimal
Jun 14, 2008·The Journal of Biological Chemistry·Ileana RamazzinaRiccardo Percudani
Sep 16, 2000·Molecular Membrane Biology·H de Koning, G Diallinas

Related Concepts

Uracil permease, Yarrowia lipolytica
DAL4 protein, S cerevisiae
DAL5 protein, S cerevisiae
Enzyme Induction
Genes, Fungal
Operon
Regulatory Sequences, Nucleic Acid
Poly(A) Tail
Saccharomyces cerevisiae
Restriction Mapping

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