The alpha 2-adrenergic system of the platelet in cystic fibrosis

The American Journal of the Medical Sciences
P B DavisC F Doershuk

Abstract

The ability of norepinephrine to inhibit prostaglandin E1 (PGE1)-stimulated accumulation of adenosine 3':5' cyclic monophosphate (cyclic AMP) in intact washed platelets was determined in 12 patients with cystic fibrosis, 6 parents of patients with cystic fibrosis, and a total of 21 healthy age-matched controls. Patients with cystic fibrosis and their parents did not differ from their age-matched controls in basal or PGE1-stimulated levels of cyclic AMP, nor in the dose dependent inhibition of cAMP accumulation by norepinephrine. Moreover, binding sites for [3H]-dihydroergocryptine were present in normal numbers and had normal ligand affinity in platelet membranes from patients with cystic fibrosis. In all measures tested, the alpha 2-adrenergic system in the platelet was normal in cystic fibrosis.

References

Apr 15, 1979·Biochemical Pharmacology·C WoodR J Lefkowitz
Nov 15, 1977·Life Sciences·M S KafkaJ L Costa
Jun 19, 1980·The New England Journal of Medicine·B B Hoffman, R J Lefkowitz
Jun 26, 1980·The New England Journal of Medicine·P B DavisM Kaliner
Jul 1, 1981·The Journal of Clinical Investigation·S P GalantC Wood
Jun 1, 1983·The Journal of Clinical Investigation·P B DavisC F Doershuk

Citations

Feb 1, 1987·Prostaglandins, Leukotrienes, and Medicine·R J SteadP Dandona
Dec 13, 2005·American Journal of Respiratory and Critical Care Medicine·Brian P O'Sullivan, Alan D Michelson
Feb 12, 2005·Blood·Brian P O'SullivanAlan D Michelson

Related Concepts

Cyclic AMP, (R)-Isomer
Teens
Caverject
Blood Platelets
Pulmonary Cystic Fibrosis
Ergot Alkaloids, Hydrogenated
Norepinephrine, (+, -)-Isomer
Prostaglandins E
Alpha-adrenergic receptor
In Vitro [Publication Type]

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