The Alpha-2A Adrenergic Receptor Gene -1291C/G Single Nucleotide Polymorphism is Associated with the Efficacy of Methylphenidate in Treating Taiwanese Children and Adolescents with Attention-Deficit Hyperactivity Disorder

Psychiatry Investigation
Hui-Ching HuangChao-Zong Liu

Abstract

The therapeutic effect of methylphenidate (MPH) in treating attention-deficit/hyperactivity disorder (ADHD) has been related to the alpha-2A adrenergic receptor (ADRA2A) gene -1291C/G single nucleotide polymorphism (SNP). We investigated the effect of MPH in treating Taiwanese children and adolescent with ADHD and its relation to the ADRA2A gene -1291C/G SNP. The subjects with DSM-IV ADHD diagnosis underwent a titration period to find out the dose of MPH for maintenance treatment. After 4 weeks maintenance treatment, the effect of MPH was evaluated by the Swanson, Nolan and Pelham version IV total scores. The subjects with more than 25% score reduction were referred to responders and those with ≥50% improvement were considered as better responders. The -1291C/G variant of the ADRA2A gene was identified by DNA sequencing and what relevance it has to the MPH response was examined by binary logistic regression analysis. Of the 59 subjects, 44 (74.6%) were responsive to MPH treatment and the responsiveness was not shown to be associated with the ADRA2A gene -1291C/G SNP. As the responsive subjects were categorized as moderate responders and better responders and subjected to statistical analysis, the GG homozygotes showed a greater...Continue Reading

References

May 30, 2003·Biochemical Society Transactions·M R RedinboP M Potter
Apr 15, 2004·The Journal of Pharmacology and Experimental Therapeutics·Zejin SunWilliam F Bosron
Jan 14, 2005·The New England Journal of Medicine·Marsha D Rappley
Jun 14, 2005·Biological Psychiatry·Amy F T Arnsten, Bao-Ming Li
Jun 30, 2006·Biological Psychiatry·Marcelo SchmitzLuis Augusto Rohde
Jan 11, 2007·Clinical Therapeutics·Margaret SteeleDeclan M P Quinn
Feb 21, 2008·International Journal of Methods in Psychiatric Research·Susan Shur-Fen GauChang-Ling Tu
Dec 17, 2008·Journal of Pediatric Psychology·Susan Shur-Fen GauShih-Kai Liu
Sep 8, 2009·Neuropharmacology·Zsofia NemodaMaria Sasvari-Szekely
Jul 24, 2010·Current Psychiatry Reports·L Cinnamon BidwellScott H Kollins
Sep 22, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Nao J GamoAmy F T Arnsten
Feb 4, 2011·Pediatric Research·Diane Purper-OuakilMichel Simonneau
Oct 9, 2012·Child and Adolescent Psychiatric Clinics of North America·Brigette Vaughan, Christopher J Kratochvil
May 11, 2016·JAMA : the Journal of the American Medical Association·Eugenia ChanPaul G Hammerness
Aug 16, 2016·Clinics in Laboratory Medicine·Lynn R Webster, Inna Belfer

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SPSS
Concerta

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.