PMID: 9537677Apr 16, 1998Paper

The alpha-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys

Psychopharmacology
Jenna S Franowicz, A F Arnsten

Abstract

In aged monkeys with naturally occurring catecholamine depletion, alpha-2 adrenergic agonists such as guanfacine have repeatedly been shown to improve dorsolateral prefrontal cortical function, as assessed by the spatial delayed response task. Both low (0.0001-0.001 mg/kg) and high (0.5 mg/kg) but not intermediate (0.01-0.05 mg/kg) doses of guanfacine improve spatial working memory performance in aged animals. However, it is not known whether guanfacine would similarly improve performance in young animals. In the present study, the effects of guanfacine on delayed response performance were characterized in seven young adult rhesus monkeys. Low doses of guanfacine (0.0001-0.01 mg/kg) had no effect on task performance, while high doses of guanfacine (0.1-0.7 mg/kg) significantly improved task performance. The highest doses produced mild sedation that was independent of drug effects on delayed response. The most effective dose of guanfacine was challenged with the alpha-2 antagonist idazoxan (0.1 mg/kg). This dose of idazoxan had no effect on task performance when given alone. Consistent with an alpha-2 mechanism, idazoxan significantly decreased delayed response performance in guanfacine-treated animals. These results support the...Continue Reading

Citations

Jan 29, 2002·Hippocampus·H Tanila
Apr 28, 2004·Psychopharmacology·Simon N KatnerMichael A Taffe
Aug 4, 2005·Psychopharmacology·Ulrich MüllerTrevor W Robbins
Jul 24, 2010·Current Psychiatry Reports·L Cinnamon BidwellScott H Kollins
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Christina T SiwakNorton W Milgram
Oct 20, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·M BjörklundP Riekkinen
Nov 1, 1998·Trends in Cognitive Sciences·A F Arnsten
Sep 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tyler A LeshCameron S Carter
Sep 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stan B Floresco, James D Jentsch
Jul 21, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amy F T Arnsten
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiao-Hua JiBao-Ming Li
May 10, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sandra Bond ChapmanChristopher H van Dyck
Oct 25, 2000·Anesthesiology·T Kamibayashi, M Maze
Nov 15, 2006·Current Opinion in Neurology·Elizabeth CoulthardMasud Husain
Jan 29, 2016·Brain Research·Humberto SalgadoMarco Atzori
Jan 8, 2016·Annual Review of Pharmacology and Toxicology·Amy F T Arnsten, Min Wang
Jul 20, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Thomas W McAllisterAndrew J Saykin
Dec 5, 2015·Frontiers in Psychiatry·Seong-Wook KimSukchan Lee
Feb 17, 2007·Pharmacology & Therapeutics·Brian P Ramos, Amy F T Arnsten
Apr 25, 2012·Annals of the New York Academy of Sciences·Teppo Särkämö, David Soto
Nov 24, 1999·Biological Psychiatry·E J NestlerG K Aghajanian
Jan 15, 2011·Behavioural Brain Research·Zafar U Khan, E Chris Muly
Aug 13, 2010·Clinical Rehabilitation·Victoria Singh-Curry, Masud Husain
Sep 3, 2011·The European Journal of Neuroscience·Emmanuel DecampJay S Schneider
Jun 18, 2019·Behavioural Pharmacology·Andresa Heemann BettiStela Maris Kuze Rates
Feb 12, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Susan L Andersen, Carryl P Navalta

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