The alpha-adrenoceptor control of adrenocorticotropin secretion in man

The Journal of Clinical Endocrinology and Metabolism
I LancranjanJ Girard

Abstract

Oral administration to six normal male volunteers of an alpha-adrenoceptor agonist, guanfacine (4 mg daily for 4 days) had no significant effect on ACTH release induced by metyrapone (a single oral 1-g dose). The same treatment with guanifacine significantly reduced ACTH secretion stimulated by insulin-induced hypoglycemia in another group of six male volunteers. These results indicate that, in man, the adrenergic system has an inhibitory input on stress-induced ACTY secretion via alpha-adrenoceptors. The concept of alpha-adrenergic control of ACTH secretion in man is in agreement with some experimental in vivo and in vitro data recorded in animals.

Citations

Jan 1, 1992·Psychiatry Research·R G KatholB M Sherman
Sep 1, 1986·Neurobiology of Aging·E HollanderK L Davis
Dec 1, 1983·Clinical Endocrinology·N FrisinaM Buemi
Mar 1, 1991·Journal of Endocrinological Investigation·S al-Damluji
Nov 1, 1985·Journal of the American Geriatrics Society·B M DavisK L Davis
Jan 1, 1980·British Journal of Clinical Pharmacology·I Lancranjan

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