The alpha-fetoprotein third domain receptor binding fragment: in search of scavenger and associated receptor targets

Journal of Drug Targeting
G J Mizejewski

Abstract

Recent studies have demonstrated that the carboxyterminal third domain of alpha-fetoprotein (AFP-CD) binds with various ligands and receptors. Reports within the last decade have established that AFP-CD contains a large fragment of amino acids that interact with several different receptor types. Using computer software specifically designed to identify protein-to-protein interaction at amino acid sequence docking sites, the computer searches identified several types of scavenger-associated receptors and their amino acid sequence locations on the AFP-CD polypeptide chain. The scavenger receptors (SRs) identified were CD36, CD163, Stabilin, SSC5D, SRB1 and SREC; the SR-associated receptors included the mannose, low-density lipoprotein receptors, the asialoglycoprotein receptor, and the receptor for advanced glycation endproducts (RAGE). Interestingly, some SR interaction sites were localized on the AFP-derived Growth Inhibitory Peptide (GIP) segment at amino acids #480-500. Following the detection studies, a structural subdomain analysis of both the receptor and the AFP-CD revealed the presence of epidermal growth factor (EGF) repeats, extracellular matrix-like protein regions, amino acid-rich motifs and dimerization subdomains. ...Continue Reading

References

Jun 9, 1989·Science·D C CarterT Y Miller
Jan 1, 1983·Annals of the New York Academy of Sciences·V ZizkovskýJ Korcáková
Jun 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G J Mizejewski
Sep 1, 1997·Proceedings of the Society for Experimental Biology and Medicine·G J Mizejewski
Nov 18, 2000·Breast Cancer Research and Treatment·D Vakharia, G J Mizejewski
Feb 7, 2002·The Biochemical Journal·Oliver PolitzSergij Goerdt
Aug 15, 2002·Biochemical and Biophysical Research Communications·Aurélie AtemezemLiliane Gattegno
Dec 31, 2002·Expert Review of Anticancer Therapy·Gerald J Mizejewski
Mar 5, 2003·European Journal of Immunology·Heikki IrjalaSirpa Jalkanen
Sep 10, 2004·The Journal of Biological Chemistry·Floris J BikkerJan Mollenhauer
Jan 19, 2006·Journal of Cellular Physiology·Kanokwan CharoonpatrapongJoseph P Bidwell
Feb 14, 2006·Current Protein & Peptide Science·Gerald J Mizejewskia, George Butterstein
Oct 10, 2007·Biochemistry. Biokhimii︠a︡·A A Terentiev, N T Moldogazieva
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu HuangDa-Jin Li
May 1, 2008·Journal of Drug Targeting·Galina A PosypanovaEvgeny S Severin
May 14, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hiroo SatohMotohiro Takeya
Jan 6, 2009·Immunological Reviews·Noah W Palm, Ruslan Medzhitov
Jun 19, 2009·Molecular Immunology·Carine M GonçalvesAlexandre M Carmo
Jan 23, 2010·The American Journal of Pathology·Danh Tran-Thanh, Susan J Done
Mar 5, 2010·International Journal of Cancer. Journal International Du Cancer·Gerald J Mizejewski
Apr 13, 2010·Analytical Biochemistry·Ronald Ian William OsmondMichael Francis Crouch
Dec 2, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gerald J Mizejewski
May 11, 2011·Molecular Neurodegeneration·Sunil S ReddyWilliam Rebeck
May 20, 2011·Clinical and Experimental Immunology·M YamamotoT Takehara
Sep 20, 2011·Doklady. Biochemistry and Biophysics·A V GodovannyiN V Gnuchev
Dec 15, 2011·Biochemical and Biophysical Research Communications·Young Ju Lee, Seong-Wook Lee
Jun 1, 2012·Journal of Biomedicine & Biotechnology·N V PozdniakovaE S Severin
Jun 26, 2012·Journal of Molecular Biology·Yingnan ZhangDaniel Kirchhofer

❮ Previous
Next ❯

Citations

Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·G J Mizejewski
Oct 4, 2016·Fetal and Pediatric Pathology·Nisha A Lakhi, Gerald J Mizejewski
Dec 4, 2016·Bioscience Reports·Bo LinMengsen Li
Jun 28, 2017·International Journal of Cancer. Journal International Du Cancer·Bo LinMengsen Li
Nov 8, 2018·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·S A ZamorinaV A Chereshnev
Jan 5, 2018·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·V A ChereshnevM B Raev
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Bo LinMengsen Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.