Recent work in the alpha thalassaemia field has started to provide some indication of the mechanisms involved in the very high frequency of the different forms of alpha thalassaemia among the populations of tropical countries, and, at the same time, is starting to define at least some of the mechanisms for its remarkable phenotypic heterogeneity. These diseases continue to provide extremely valuable models for the better understanding of the regulation of the alpha globin genes, and for human molecular pathology in general. The much less common disorders, ATR-16 and ATR-X are also providing valuable information about the spectrum of molecular lesions associated with different forms of mental retardation and about the molecular mechanisms involved in their varying phenotypes.
Familial Mediterranean fever with a single MEFV mutation: can a deletion resulting in α-thalassemia be the cause?
Thalassaemia in Vanuatu, south-west Pacific: frequency and haematological phenotypes of young children
Hb H disease resulting from the association of an α-thalassemia allele [-(α)] with an unstable α-globin variant [Hb Icaria]: First report on the occurrence in Brazil
Prevalence of common α-thalassemia determinants in south Brazil: Importance for the diagnosis of microcytic anemia
Detection of acquired hemoglobinopathy in children with hematological malignancies at disease onset: results form a national referral centre
A rapid single-tube multiplex polymerase chain reaction assay for the seven most prevalent alpha-thalassemia deletions and alphaalphaalpha(anti 3.7) alpha-globin gene triplication
Variable presentation of HB H disease due to homozygosity for the rare polyadenylation signal A T(Indian) (AATAAA>AATA- -) mutation in four Indian families
Hemoglobin H disease due to a de novo mutation at the α2-globin gene and an inherited common α-thalassemia deletion found in a Chinese boy
Novel large deletions in the human alpha-globin gene cluster: Clarifying the HS-40 long-range regulatory role in the native chromosome environment
Development and validation of a high throughput, closed tube method for the determination of haemoglobin alpha gene (HBA1 and HBA2) numbers by gene ratio assay copy enumeration-PCR (GRACE-PCR)
Capillary electrophoresis combining three-step multiplex polymerase chain reactions for diagnosing α-thalassemia
Thalassemia as a global health problem: recent progress toward its control in the developing countries
Evidence of differential selection for the -α(3.7) and -α(4.2) single-α-globin gene deletions within the same population
Identification and molecular characterization of the --CAMPANIA deletion, a novel alpha (0) -thalassemic defect, in two unrelated Italian families [corrected
Detection of α-Thalassemia by Using Multiplex Ligation-Dependent Probe Amplification as an Additional Method for Rare Mutations in Southern Turkey
A novel fusion gene and a common α(0)-thalassemia deletion cause hemoglobin H disease in a Chinese family
Microsatellite markers within the α-globin gene cluster for robust preimplantation genetic diagnosis of severe α-thalassemia syndromes in Mediterranean populations
Molecular characterization of Hb Hamilton Hill (HBA2: c.388delC), a novel HBA2 variant generating a premature termination codon and truncated HBA2 chain
Characterization of Hb Calvino (HBB: c.406G > A): a new silent β-globin gene variant found in coexistence with α-thalassemia in a family of African origin
Development and clinical implementation of a combination deletion PCR and multiplex ligation-dependent probe amplification assay for detecting deletions involving the human α-globin gene cluster
Detection of germline rearrangements in patients with α- and β-thalassemia using high resolution array CGH
Homozygous deletion of the major alpha-globin regulatory element (MCS-R2) responsible for a severe case of hemoglobin H disease
A simple and highly sensitive ELISA for screening of the α-thalassemia-1 Southeast Asian-type deletion
Prevalence of α(+)-Thalassemia in the Scheduled Tribe and Scheduled Caste Populations of Damoh District in Madhya Pradesh, Central India
Characterization of alpha thalassemic genotypes by multiplex ligation-dependent probe amplification in the Brazilian population
Causes of microcytic anaemia and evaluation of conventional laboratory parameters in the differentiation of erythrocytic microcytosis in blood donors candidates
A modified sandwich ELISA for accurate measurement of HbF in α-thalassemia carriers containing Hb Bart's and Hb Portland 1
Characterization of Hb Bart's Hydrops Fetalis Caused by - -SEA and a Large Novel α0 -Thalassemia Deletion
A case of mild thalassemic syndrome caused by interaction of Hb Adana with an alpha+-thalassemia deletion
Recent progress in laboratory diagnosis of thalassemia and hemoglobinopathy: a study by the Korean Red Blood Cell Disorder Working Party of the Korean Society of Hematology
A novel deletion of the major regulatory element flanking the α-globin gene cluster as a cause of α0 -thalassemia.
Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.