The Alpha-Tocopherol Form of Vitamin E Boosts Elastase Activity of Human PMNs and Their Ability to Kill Streptococcus pneumoniae

Frontiers in Cellular and Infection Microbiology
Elsa N Bou GhanemAlexander Panda

Abstract

Despite the availability of vaccines, Streptococcus pneumoniae remains a leading cause of life-threatening infections, such as pneumonia, bacteremia and meningitis. Polymorphonuclear leukocytes (PMNs) are a key determinant of disease course, because optimal host defense requires an initial robust pulmonary PMN response to control bacterial numbers followed by modulation of this response later in infection. The elderly, who manifest a general decline in immune function and higher basal levels of inflammation, are at increased risk of developing pneumococcal pneumonia. Using an aged mouse infection model, we previously showed that oral supplementation with the alpha-tocopherol form of vitamin E (α-Toc) decreases pulmonary inflammation, in part by modulating neutrophil migration across lung epithelium into alveolar spaces, and reverses the age-associated decline in resistance to pneumococcal pneumonia. The objective of this study was to test the effect of α-Toc on the ability of neutrophils isolated from young (22-35 years) or elderly (65-69 years) individuals to migrate across epithelial cell monolayers in response to S. pneumoniae and to kill complement-opsonized pneumococci. We found that basal levels of pneumococcal-induced tr...Continue Reading

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Citations

Apr 4, 2020·American Journal of Respiratory Cell and Molecular Biology·Brant M WagenerJean-Francois Pittet
Nov 23, 2018·IUBMB Life·Roberto MendezSantanu Banerjee
Feb 6, 2020·Journal of Leukocyte Biology·Nalat SiwapornchaiElsa N Bou Ghanem
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Jan 27, 2021·Infection and Immunity·Shaunna R SimmonsElsa N Bou Ghanem
Dec 2, 2020·Medical Hypotheses·Hanjun Lee
Aug 12, 2021·Trends in Molecular Medicine·Bharathi SundareshTim van Opijnen

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Methods Mentioned

BETA
immunodepletion
bronchoalveolar lavage
blood draw
ELISA
flow cytometry
Assay
ELISAs

Software Mentioned

Graph Pad
Prism5

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