PMID: 11905992Mar 22, 2002Paper

The alpha7 nicotinic receptors in human fetal brain and spinal cord

Journal of Neurochemistry
Lena FalkEwa Hellström-Lindahl

Abstract

The alpha7 nicotinic acetylcholine receptor subtype is believed to be involved in the regulation of neuronal growth, differentiation and synapse formation during the development of the human brain. In this study the expression of the alpha7 nicotinic acetylcholine receptor was investigated in human fetal brain and spinal cord of 5-11 weeks gestational age. Both the specific binding of [125I]alpha-bungarotoxin to prenatal brain membranes and the expression of alpha7 mRNA were significantly higher in the pons, medulla oblongata, mesencephalon and spinal cord of 9-11 weeks gestational age compared with cerebellum, cortex and subcortical forebrain. A significant positive correlation between gestational age and the expression of alpha7 mRNA was observed in all brain regions except cortex. A positive correlation was also observed between the gestational age and the [125I]alpha-bungarotoxin binding in the pons, medulla oblongata, mesencephalon, and cerebellum. Consequently, a significant relationship between the alpha7 mRNA levels and the binding sites for [125I]alpha-bungarotoxin was found in the fetal brain. The increasing levels of the alpha7 nicotinic acetylcholine receptor during the first trimester support the important role of ...Continue Reading

Citations

Apr 25, 2003·Brain Research. Developmental Brain Research·Lena FalkEwa Hellström-Lindahl
May 23, 2014·The Journal of Steroid Biochemistry and Molecular Biology·M HillL Stárka
Jan 12, 2010·Behavioural Brain Research·Yael Abreu-VillaçaAlex C Manhães
Mar 10, 2009·Pharmacology & Therapeutics·Jennifer B DwyerFrances M Leslie
Oct 6, 2009·Journal of Cellular and Molecular Medicine·Mats NilbrattAgneta Nordberg
Jan 15, 2005·Progress in Neurobiology·C Gotti, F Clementi
May 13, 2006·Brain Research·Minjung K ParkFrances M Leslie
May 1, 2006·Environmental Toxicology and Pharmacology·E Pretorius, J Marx
Nov 28, 2002·The Journal of Comparative Neurology·C Jane H KeigerRonald W Oppenheim
Nov 19, 2002·Journal of Neurobiology·Edna F R PereiraEdson X Albuquerque
Apr 3, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Jennifer B DwyerFrances M Leslie
Aug 27, 2019·Frontiers in Neuroanatomy·Ron S BroideFrances M Leslie
Jul 17, 2020·Frontiers in Molecular Neuroscience·Ayman Alzu'biGavin J Clowry
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthias FischerFrank Berthold

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