The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins

Intrinsically Disordered Proteins
Vladimir N Uversky

Abstract

The ability of a protein to fold into unique functional state or to stay intrinsically disordered is encoded in its amino acid sequence. Both ordered and intrinsically disordered proteins (IDPs) are natural polypeptides that use the same arsenal of 20 proteinogenic amino acid residues as their major building blocks. The exceptional structural plasticity of IDPs, their capability to exist as heterogeneous structural ensembles and their wide array of important disorder-based biological functions that complements functional repertoire of ordered proteins are all rooted within the peculiar differential usage of these building blocks by ordered proteins and IDPs. In fact, some residues (so-called disorder-promoting residues) are noticeably more common in IDPs than in sequences of ordered proteins, which, in their turn, are enriched in several order-promoting residues. Furthermore, residues can be arranged according to their "disorder promoting potencies," which are evaluated based on the relative abundances of various amino acids in ordered and disordered proteins. This review continues a series of publications on the roles of different amino acids in defining the phenomenon of protein intrinsic disorder and concerns glutamic acid, ...Continue Reading

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Citations

Feb 6, 2018·Chembiochem : a European Journal of Chemical Biology·Ferenc Zsila
Jan 9, 2019·AIDS Research and Human Retroviruses·Priyanka NamdevRajaneesh Anupam
Jun 7, 2019·The Journal of Biological Chemistry·Shibani BhattacharyaZimei Bu
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Jul 3, 2019·Entropy·Jiří VymětalKlára Hlouchová
Jan 9, 2021·BMC Molecular and Cell Biology·Djaleel Muhammad SoyfooShun-Fu Xu
Mar 26, 2021·Brain : a Journal of Neurology·Leslie E SandersonNamik Kaya
Apr 8, 2021·Journal of Chemical Theory and Computation·Andrew P Latham, Bin Zhang
Jun 1, 2021·NAR Genomics and Bioinformatics·Katarzyna ChyżyńskaEivind Valen
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Nov 23, 2019·Journal of Chemical Theory and Computation·Andrew P Latham, Bin Zhang
Oct 12, 2021·European Biophysics Journal : EBJ·Miguel MompeánDouglas V Laurents

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Methods Mentioned

BETA
protein folding
deacylation
deamidation
X-ray
electron microscopy
GTPase

Software Mentioned

Medusa

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