The alteration of gamma-aminobutyric acid-transaminase expression in the gerbil hippocampus induced by seizure

Neurochemistry International
T C KangMoo Ho Won

Abstract

It is well established that GABA degradation may play a key role in epileptogenesis. However, whether or not the expression of GABA-transaminase (GABA-T), which catalyzes GABA degradation and participates in the neuronal metabolism via GABA shunt, changes chronologically after on-set of seizure remains to be clarified. To identify the change of GABA-T expression in seizure, GABA-T expression in the gerbil hippocampus, associated with different sequelae of spontaneous seizures, was investigated. The distribution pattern of GABA-T immunoreactive neurons in the hippocampus between the seizure-resistant and pre-seizure group of seizure sensitive gerbils was similar. Interestingly, at 30 min postictal, the enhancement of GABA-T immunoreactivity in the perikarya was apparently observed. This contrasted with the decline in GABA-T immunoreactivity in the granular and pyramidal layer. At 12-24 h postictal, GABA-T immunoreactivity in the hilar neurons had declined significantly. However, the GABA-T immunoreactivity in the granular layer increased. These findings suggest that in the gerbil, the alteration in GABA-T expressions may play an important role in the self-recovery mechanism from seizure attack via both GABA degradation and regul...Continue Reading

References

Aug 28, 2003·Brain Research. Molecular Brain Research·Tae-Cheon KangMoo Ho Won
Oct 22, 2003·Neurochemistry International·In Koo HwangMoo Ho Won
Mar 19, 2005·The Journal of Comparative Neurology·Sung-Eun KwakTae-Cheon Kang

Citations

Dec 1, 1992·Clinical Neuropharmacology·J A ArmijoJ L Herranz
Jul 15, 1987·The Journal of Comparative Neurology·G M Peterson, C E Ribak
Mar 1, 1983·Journal of Neurochemistry·H K WardH F Bradford
Jan 1, 1984·Journal of Neurochemistry·O Giorgi, J L Meek
Aug 1, 1983·The Journal of Comparative Neurology·T NagaiE G McGeer
May 1, 1993·The Histochemical Journal·P Kugler
Mar 31, 1999·Neurochemistry International·K K YungF S Kwok
Jul 9, 1999·Neurochemistry International·E S Vizi, B Sperlágh
Jul 9, 1999·Neurochemistry International·J M FritschyF Loup

Related Concepts

Metabolic Process, Cellular
Psammomys
Immunoreactivity
Neurons
Stratum Granulosum
Menopause
Immunocytochemistry
ABAT gene
Western Blot
Genus Hippocampus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.