The altered fate of aging satellite cells is determined by signaling and epigenetic changes

Frontiers in Genetics
Maura H Parker

Abstract

Skeletal muscle is a striated tissue composed of multinucleated fibers that contract under the control of the somatic nervous system to direct movement. The stem cells of skeletal muscle, known as satellite cells, are responsible for muscle fiber growth, turnover, and regeneration. Satellite cells are activated and proliferate in response to stimuli, and simplistically, have two main fates-to repopulate the satellite cell niche, or differentiate to regenerate or repair muscle fibers. However, the ability to regenerate muscle and replace lost myofibers declines with age. This loss of function may be a result of extrinsic changes in the niche, such as alterations in signaling or modifications to the extracellular matrix. However, intrinsic epigenetic changes within satellite cells may also affect cell fate and cause a decline in regenerative capacity. This review will describe the mechanisms that regulate cell fate decisions in adult skeletal muscle, and how changes during aging affect muscle fiber turnover and regeneration.

References

Dec 1, 1987·Journal of Cellular Physiology·R E Allen, L K Boxhorn
Feb 1, 1982·Muscle & Nerve·S I Zacks, M F Sheff
Jan 31, 2003·The Journal of Biological Chemistry·Joshua R Sanes
Dec 4, 2003·Science·Irina M ConboyThomas A Rando
Dec 23, 2003·Journal of the American Geriatrics Society·Ian JanssenRonenn Roubenoff
Dec 1, 2004·Aging Cell·Marjorie L BeggsCharlotte A Peterson
Apr 13, 2005·The Journal of Cell Biology·Nathan C JonesBradley B Olwin
Mar 24, 2006·Developmental Biology·Gabi SheferZipora Yablonka-Reuveni
Jun 27, 2006·Nature Cell Biology·Vasily ShininShahragim Tajbakhsh
Dec 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Karin Schuster-GosslerAchim Gossler
Feb 16, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kate A CareyDavid Cameron-Smith
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Elena VasyutinaCarmen Birchmeier
May 4, 2007·American Journal of Physiology. Cell Physiology·Catherine AlexakisGeorge Bou-Gharios
Jun 2, 2007·Cell·Shihuan KuangMichael A Rudnicki
Jul 3, 2007·Nature·Tarjei S MikkelsenBradley E Bernstein
Jul 20, 2007·Nature·Ander MatheuManuel Serrano
Sep 21, 2007·Clinical and Experimental Pharmacology & Physiology·John A FaulknerSusan V Brooks
Feb 26, 2009·Aging Cell·Ander MatheuManuel Serrano
Jan 6, 2010·EMBO Molecular Medicine·Morgan E CarlsonIrina Conboy
Jul 16, 2010·The Biochemical Journal·Ana Cuadrado, Angel R Nebreda
Aug 7, 2010·Experimental Gerontology·Tomasz GeorgeStephen D R Harridge
Sep 3, 2010·PloS One·Matthew A SchallerSteven L Kunkel
Sep 3, 2010·American Journal of Physiology. Cell Physiology·Frédéric TrenszGuillaume Grenier
Jan 21, 2011·Nature·Raphaël Margueron, Danny Reinberg
Feb 16, 2011·The Journal of Cell Biology·Francis Rodier, Judith Campisi

❮ Previous
Next ❯

Citations

Jul 1, 2020·Journal of Cachexia, Sarcopenia and Muscle·Ariane C ScheurenRalph Müller
Apr 23, 2017·Journal of Cachexia, Sarcopenia and Muscle·Kerstin BoenglerSusanne Rohrbach
Dec 7, 2018·Cells·Christian KosanHolger Bierhoff
Nov 14, 2018·Cell and Tissue Research·Mohamed A A Mahdy
Aug 17, 2019·Biomaterials·Jason WangNenad Bursac
Jan 13, 2021·Skeletal Muscle·Jimmy MassenetF Jeffrey Dilworth

❮ Previous
Next ❯

Methods Mentioned

BETA
FACS

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Related Papers

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Vincent G PunchMichael A Rudnicki
Neurological Research
Arianna CorbuGiovanna Cenacchi
© 2022 Meta ULC. All rights reserved