The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice

PloS One
Chenghao XuFanfan Zhou

Abstract

Diabetes mellitus is a chronic metabolic disorder that significantly affects human health and well-being. The Solute carrier transporters (SLCs), particularly the Organic anion/cation transporters (Oats/Octs/Octns), Organic anion transporting polypeptides (Oatps) and Oligopeptide transporters (Pepts) are essential membrane proteins responsible for cellular uptake of many endogenous and exogenous substances such as clinically important drugs. They are widely expressed in mammalian key organs especially the kidney and liver, in which they facilitate the influx of various drug molecules, thereby determining their distribution and elimination in body. The altered expression of SLCs in diabetes mellitus could have a profound and clinically significant influence on drug therapies. In this study, we extensively investigated the renal and hepatic expression of twenty essential SLCs in the type 1 diabetic Ins2Akita murine model that develops both hyperglycemia and diabetes-related complications using real-time PCR and immunoblotting analysis. We found that the renal expression of mOatp1a1, mOatp1a6, mOat1, mOat3, mOat5, mOct2 and mPept2 was decreased; while that of mPept1 was increased at the mRNA level in the diabetic mice compared wit...Continue Reading

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Citations

Nov 30, 2018·Diabetes·Dorela D Shuboni-MulliganErik M Shapiro
Sep 18, 2018·Clinical Pharmacology and Therapeutics·Lindsey H M Te BrakeUNKNOWN TANDEM Consortium
Sep 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marek DroździkAgnieszka Droździk

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

RefFinder
Relative Expression Software Tool
Graphpad Prism

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