Abstract
We compared the common pathway components C3a, C5a and membrane attack complex (MAC), also known as C5b-9, and the alternative pathway components factor B and properdin in patients with ANCA-associated vasculitis (AAV) and healthy controls, and conducted a meta-analysis of the available clinical evidence for the role of complement activation in the pathogenesis of AAV. Complement components were evaluated in 59 patients with newly diagnosed or relapsing granulomatosis with polyangiitis or microscopic polyangiitis and 36 healthy volunteers. In 28 patients, testing was repeated in remission. Next, we performed a meta-analysis by searching databases to identify studies comparing complement levels in AAV patients and controls. A random-effects model was used for statistical analyses. The median concentrations of MAC, C5a, C3a and factor B were higher in active AAV patients (P < 0·001). Achievement of remission was associated with reductions in C3a (P = 0·005), C5a (P = 0·035) and factor B levels (P = 0·045), whereas MAC and properdin levels did not change. In active AAV, there were no effects of ANCA specificity, disease phenotype, previous immunosuppression or disease severity on complement levels. A total of 1122 articles were sc...Continue Reading
References
Aug 1, 1990·Arthritis and Rheumatism·R Y LeavittR W Lightfoot
Oct 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I M BajemaJ A Bruijn
Aug 12, 2006·Annals of the Rheumatic Diseases·Richard WattsDavid Scott
Jan 4, 2007·The American Journal of Pathology·Hong XiaoJ Charles Jennette
Dec 17, 2008·Journal of the American Society of Nephrology : JASN·Adrian SchreiberRalph Kettritz
Jul 10, 2010·Journal of the American Society of Nephrology : JASN·Annelies E BerdenIngeborg M Bajema
Jun 14, 2012·Arthritis Research & Therapy·Jun YuanMing-Hui Zhao
Aug 24, 2012·Kidney International·Shen-Ju GouMing-Hui Zhao
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Oct 12, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Shen-Ju GouMin Chen
Nov 2, 2013·Journal of the American Society of Nephrology : JASN·Hong XiaoJ Charles Jennette
Aug 16, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marc HilhorstUNKNOWN Limburg Renal Registry
Sep 28, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andreas KronbichlerMichael Rudnicki
Mar 21, 2017·Nature Reviews. Nephrology·Min ChenMing-Hui Zhao
Apr 13, 2017·Journal of the American Society of Nephrology : JASN·David R W JayneUNKNOWN CLEAR Study Group
Apr 6, 2018·PloS One·Samuel DeshayesNicolas Martin Silva
Dec 14, 2018·Nature Reviews. Rheumatology·Daigo NakazawaAkihiro Ishizu
May 3, 2019·Rheumatology·Alfred MahrDavid Jayne
Jun 20, 2019·Arthritis & Rheumatology·Eveline Y WuDonna O Bunch
Jul 11, 2019·Molecular Immunology·Luis F QuintanaDavid Jayne
Aug 3, 2019·The Journal of Rheumatology·Aleksandra AntovicIva Gunnarsson
Oct 22, 2019·Néphrologie & thérapeutique·David Jayne
Nov 2, 2019·Clinics in Laboratory Medicine·Morris Ling, Mandakolathur Murali
Nov 18, 2019·Autoimmunity Reviews·Benoit BrillandJean-François Augusto
Citations
Oct 8, 2020·International Journal of Molecular Sciences·Andreas KronbichlerJae Il Shin
Sep 19, 2020·Clinical and Experimental Immunology·G Trivioli, A Vaglio
Feb 2, 2021·Rheumatology·Sergey MoiseevDavid R W Jayne
Apr 29, 2021·Current Rheumatology Reports·Martin WindpesslAndreas Kronbichler
Oct 9, 2021·JCI Insight·Qingmiao LuChunsun Dai