PMID: 8597600Mar 1, 1996Paper

The alternative exons 1 of the mouse aromatase cytochrome P-450 gene

Biochimica Et Biophysica Acta
Shin-Ichiro HondaY Takagi

Abstract

Aromatase cDNA clones were isolated from cDNA libraries of mouse hypothalamus, amygdala and ovary. Analysis of the nucleotide sequences of the 5' regions of the obtained cDNAs suggested that the mouse aromatase gene is tissue-specifically regulated by alternative exons 1. There were obvious differences between the 5' regions of the brain and ovary aromatase cDNAs, but no difference was found between the sequences of the hypothalamus and amygdala ones. We further isolated a mouse genomic DNA clone containing brain- and ovary-specific exons 1. The brain specific exons 1 and their promoters were highly homologous in the human and mouse aromatase genes. In contrast there were several differences in the sequences among the promoter regions of the ovary-specific exons 1 of the mouse, human and rat aromatase genes, significant homology between their sequences was also observed. The present results demonstrate that expression of the mouse aromatase gene is also tissue-specifically regulated through the use of alternative exons 1 and promoters, as reported for man.

References

Jan 1, 1978·The Journal of Clinical Endocrinology and Metabolism·C LongcopeS E Fineberg
Nov 1, 1977·The Journal of Clinical Endocrinology and Metabolism·M Smuk, J Schwers
Sep 1, 1992·Brain Research. Molecular Brain Research·N HaradaJ Balthazart
Jan 1, 1991·Annual Review of Cell Biology·M R Green
Jan 1, 1991·Cell and Tissue Research·J BalthazartN Harada
Jan 15, 1990·Biochemical and Biophysical Research Communications·N HaradaY Takagi
Apr 30, 1990·Brain Research·J BalthazartN Harada
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C J CorbinE R Simpson
Oct 31, 1988·Biochemical and Biophysical Research Communications·N Harada
Jan 29, 1986·Biochemical and Biophysical Research Communications·S NakajinP F Hall
Feb 15, 1994·Biochemical and Biophysical Research Communications·S HondaY Takagi

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Citations

Jun 16, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Nobuhiro Harada, Shin-ichiro Honda
Dec 18, 2001·Brain Research. Brain Research Reviews·E D LephartT L Horvath
May 24, 2000·The Journal of Steroid Biochemistry and Molecular Biology·L G GraddyR C Simmen
Feb 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·S I HondaN Harada
Feb 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·J VanselowM Schwerin
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Sok-Keng Tong, Bon-chu Chung
Feb 4, 1998·The Journal of Steroid Biochemistry and Molecular Biology·M YoungM J McPhaul
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·J B HutchisonR E Hutchison
Mar 15, 2002·Trends in Endocrinology and Metabolism : TEM·Amrita KamatCarole R Mendelson
May 7, 1998·The International Journal of Biochemistry & Cell Biology·K GrandienJ A Gustafsson
Apr 3, 2010·BMC Neuroscience·Sarah E London, David F Clayton
Apr 28, 2009·Reproductive Biology and Endocrinology : RB&E·Hong ZhaoSerdar E Bulun
Apr 26, 2011·The Journal of Steroid Biochemistry and Molecular Biology·G V CallardK A Cotter
Jun 9, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Jenny D Y ChowWah Chin Boon
Feb 21, 2008·Toxicology and Applied Pharmacology·Lan Ye, Lai K Leung
Apr 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·J M TrantJ Wunder
Nov 3, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Norman NauschJens Vanselow
Mar 31, 2007·Molecular Reproduction and Development·Yuki Ohmuro-MatsuyamaYoshitaka Nagahama
Mar 4, 2008·Journal of Neurochemistry·Ryan D WynneColin J Saldanha
Feb 20, 2009·Journal of Neuroendocrinology·N HaradaS-I Honda
May 29, 2014·Journal of Fish Biology·X W ChenZ Y Shi
Apr 14, 2016·Journal of Molecular Endocrinology·Hong ZhaoSerdar E Bulun
Nov 11, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Malgorzata BielinskaDavid B Wilson
Jun 2, 2011·Journal of Molecular Endocrinology·M Bertan YilmazSerdar E Bulun
May 28, 2005·Endocrinology·Malgorzata BielinskaDavid B Wilson
Dec 24, 1997·DNA and Cell Biology·S H LeeM M Mouradian
Jun 26, 2020·Frontiers in Endocrinology·Shin-Ichiro Honda, Nobuhiro Harada
Jun 10, 2009·Frontiers in Neuroendocrinology·Jean Luc Do RegoHubert Vaudry

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