The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions

Medical Hypotheses
Kiyotoshi Kaneko, Naomi S Hachiya

Abstract

Here, we propose a novel hypothesis that 14-3-3 zeta might act as a sweeper of misfolded proteins by facilitating the formation of aggregates, which are referred to as inclusion bodies. Studies on the localization of the 14-3-3 proteins in different types of inclusion bodies in the brain including neurofibrillary tangle in Alzheimer's disease, pick bodies in Pick's disease, Lewy body-like hyaline inclusions in sporadic amyotrophic lateral sclerosis, prion/florid plaques in sporadic/variant Creutzfeldt-Jakob disease, nuclear inclusions in spinocerebellar ataxia-1, and possibly Lewy bodies in Parkinson's disease suggest a close association of these diseases with 14-3-3 zeta. The highly conserved hydrophobic surface of the amphipathic groove in 14-3-3 zeta represents a general mechanism with diverse cellular proteins, and it may also allow for the molecular recognition of misfolded proteins by hydrophobic interaction in disease conditions. When the abnormal processing of misfolded proteins overwhelms the quality control systems of the cell, it is likely that 14-3-3 zeta is recruited to form deposits of protein aggregates with nonnative, misfolded proteins in order to protect the cell against toxicity. Hence, 14-3-3 zeta may be con...Continue Reading

References

Nov 22, 2001·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·W A Houry
Sep 3, 2003·Nature Reviews. Neuroscience·Daniela BergOlaf Riess
Mar 24, 2004·Neuroscience Letters·Félix HernándezJesús Avila
May 25, 2004·Science·J Timothy Greenamyre, Teresa G Hastings
Jul 24, 2004·Nature Medicine·Christopher A Ross, Michelle A Poirier
Nov 3, 2004·Neuroscience Letters·Takahiko UmaharaMasaru Takasaki

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Citations

Sep 8, 2006·Acta Neuropathologica·Yoshitomo ShirakashiMasafumi Ihara
Nov 8, 2011·Journal of Neural Transmission·Martin BroadstockPaul T Francis
Sep 18, 2007·Journal of Molecular Neuroscience : MN·J Steven AlexanderStacy J Smith
Oct 10, 2008·Journal of Molecular Neuroscience : MN·Alireza MinagarMerilyn H Jennings
Nov 16, 2013·BMC Medical Genomics·Dokyun NaJörg Gsponer
Dec 24, 2013·BioMed Research International·Tadayuki ShimadaKanato Yamagata
Jan 15, 2011·International Journal of Alzheimer's Disease·Issam El GhaziIan M Armitage
Jul 17, 2012·Biochemistry·Nikolai N SluchankoNikolai B Gusev
Apr 1, 2014·Archives of Biochemistry and Biophysics·Nikolai N SluchankoNikolai B Gusev
Sep 15, 2018·Journal of Neurochemistry·D Allan Butterfield, Debra Boyd-Kimball
Jul 25, 2007·Molecular and Cellular Biochemistry·Abelardo MedinaAziz Ghahary
Feb 9, 2017·Annals of Clinical and Translational Neurology·Diana SantosAlda Sousa
Jul 29, 2018·Scientific Reports·Kaly A MuellerGhazaleh Sadri-Vakili
Jul 12, 2013·Journal of Cell Science·Zhe XuYi Zhou
Mar 9, 2021·Proteomics. Clinical Applications·Justin McKetneyJoshua J Coon

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