The alternative role of DNA methylation in splicing regulation

Trends in Genetics : TIG
Galit Lev MaorGil Ast


Although DNA methylation was originally thought to only affect transcription, emerging evidence shows that it also regulates alternative splicing. Exons, and especially splice sites, have higher levels of DNA methylation than flanking introns, and the splicing of about 22% of alternative exons is regulated by DNA methylation. Two different mechanisms convey DNA methylation information into the regulation of alternative splicing. The first involves modulation of the elongation rate of RNA polymerase II (Pol II) by CCCTC-binding factor (CTCF) and methyl-CpG binding protein 2 (MeCP2); the second involves the formation of a protein bridge by heterochromatin protein 1 (HP1) that recruits splicing factors onto transcribed alternative exons. These two mechanisms, however, regulate only a fraction of such events, implying that more underlying mechanisms remain to be found.


Jul 20, 1987·Journal of Molecular Biology·M Gardiner-Garden, M Frommer
Mar 24, 1999·Trends in Genetics : TIG·P A Jones
Sep 27, 2000·Human Molecular Genetics·T H Bestor
Jan 10, 2002·Genes & Development·Adrian Bird
Nov 13, 2002·The Journal of Biological Chemistry·Francois FuksTony Kouzarides
Jul 1, 2004·Gene·Laura E NorwoodLori L Wallrath
Oct 29, 2004·Nature Reviews. Genetics·Gil Ast
Oct 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Juan I YoungHuda Y Zoghbi
Jul 22, 2006·Molecular Cell·Roderic Guigó, Juan Valcárcel
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·C C OakesJ M Trasler
May 9, 2008·Nature Reviews. Genetics·Miho M Suzuki, Adrian Bird
Jan 13, 2009·Nature Structural & Molecular Biology·Gene W YeoFred H Gage
Feb 26, 2009·Cell·Thomas A CooperGideon Dreyfuss
Apr 18, 2009·Science·Skirmantas Kriaucionis, Nathaniel Heintz
Jun 23, 2009·Nature Structural & Molecular Biology·Mariano AllóAlberto R Kornblihtt
Aug 1, 2009·Science·Courtney HodgesCarlos Bustamante
Aug 18, 2009·Nature Structural & Molecular Biology·Schraga SchwartzGil Ast
Sep 24, 2009·Nature Reviews. Molecular Cell Biology·Mo Chen, James L Manley
Oct 1, 2009·Nature Reviews. Genetics·Peter A Jones, Gangning Liang
Jan 26, 2010·Nature Structural & Molecular Biology·Hongqing DuManuel Ares
Feb 6, 2010·Genome Research·Louise LaurentChia-Lin Wei
Apr 9, 2010·Nature Reviews. Genetics·Hadas KerenGil Ast
Aug 17, 2010·Nature Structural & Molecular Biology·Miriam LlorianChristopher W J Smith
Sep 14, 2010·Current Biology : CB·Assaf Zemach, Daniel Zilberman
Jan 11, 2011·Cell·Reini F LucoTom Misteli
May 18, 2011·Genes & Development·Aimée M Deaton, Adrian Bird
Sep 17, 2011·Nature Reviews. Genetics·Auinash Kalsotra, Thomas A Cooper
Jun 12, 2012·Genome Research·Andrea SmallwoodBing Ren
Sep 11, 2012·Nature Structural & Molecular Biology·Maya Ameyar-ZazouaAnnick Harel-Bellan
Jul 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hongmei Li-ByarlayGene E Robinson
Jul 31, 2013·The EMBO Journal·Ignacio E SchorAlberto R Kornblihtt

❮ Previous
Next ❯


Jan 17, 2016·Genomics·Kamel Jabbari, Peter Nürnberg
Mar 1, 2016·Wiley Interdisciplinary Reviews. RNA·Hsiao-Lin V Wang, Julia A Chekanova
Mar 2, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Melvin M BonillaDavid W Zeh
Oct 1, 2015·The Journal of Pathology·Ailbhe Jane Brazel, Douglas Vernimmen
Mar 10, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Nancy LévesqueRima Rozen
Oct 16, 2015·Human Molecular Genetics·Michael D RushtonJohn Loughlin
Mar 30, 2016·Seminars in Cell & Developmental Biology·Ane Sesma
Sep 16, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Tasnim Dayeh, Charlotte Ling
May 1, 2016·Seminars in Cell & Developmental Biology·Louise N Reynard
Jun 9, 2016·Translational Psychiatry·A StarnawskaM Nyegaard
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Gabriel R FriesJoao Quevedo
Apr 12, 2016·Journal of Cellular Biochemistry·Myrthe W van den DungenWilma T Steegenga
Nov 3, 2016·Molecular Ecology·Madeleine BergerChris Bass
Oct 23, 2016·The Journal of Investigative Dermatology·Ron BochnerEli Sprecher
Dec 8, 2015·PloS One·Stepan DenisovMikhail Gelfand
Apr 23, 2016·PLoS Genetics·Walid MahrezLars Hennig
Feb 18, 2017·Scientific Reports·Tian-Lin ChengZilong Qiu
May 13, 2017·Genes·Kathryn VaillancourtGustavo Turecki
Jan 1, 2016·Biologie aujourd'hui·Karine Merienne, Anne-Laurence Boutillier
Mar 16, 2018·Future Oncology·Guillermo Montalban-Bravo, Courtney D DiNardo
Dec 20, 2017·Nature Genetics·James WalkerXiaoqi Feng
Oct 17, 2017·Nucleic Acids Research·Daniel E Martin-HerranzThomas M Stubbs
Feb 23, 2018·Leukemia·Alex C H WongJustin J-L Wong
Nov 25, 2017·Scientific Reports·Yogitha N SrikhantaTerry Kwok
Aug 11, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Juan Ausió, Philippe T Georgel
Jun 19, 2018·Biology of Reproduction·Zongliang JiangXiuchun Cindy Tian
Jul 17, 2018·Journal of Biochemistry·Hidetoshi Saze
Jul 31, 2018·Genome Biology and Evolution·Jouni KvistLeda Mirbahai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.