The Alzheimer Precision Medicine Initiative

Journal of Alzheimer's Disease : JAD
Harald HampelAlzheimer Precision Medicine Initiative (APMI)

Abstract

Precision medicine (PM) is an evolving scientific renaissance movement implementing key breakthrough technological and scientific advances to overcome the limitations of traditional symptom- and sign-based phenotypic diagnoses and clinical "one-size-fits-all, magic bullet drug development" in these largely heterogeneous target populations. It is a conceptual shift from ineffective treatments for biologically heterogeneous "population averages" to individually-tailored biomarker-guided targeted therapies. PM is defining which therapeutic approach will be the most effective for a specific individual, at a determined disease stage, across multiple medical research fields, including neuroscience, neurology and psychiatry. The launch of the Alzheimer Precision Medicine Initiative (APMI) and its associated cohort program in 2016-facilitated by the academic core coordinating center run by the Sorbonne University Clinical Research Group in Alzheimer Precision Medicine (Sorbonne University GRC n°21 APM)"-is geared at transforming healthcare, conventional clinical diagnostics, and drug development research in Alzheimer's disease. Ever since the commencement of the APMI, the international interdisciplinary research network has introduced ...Continue Reading

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Citations

Jun 5, 2019·Expert Review of Molecular Diagnostics·Filippo BaldacciHarald Hampel
Jun 15, 2019·Expert Review of Proteomics·Filippo BaldacciHarald Hampel
Jul 14, 2020·Medicinal Research Reviews·Jiansong FangFeixiong Cheng
Sep 25, 2020·Journal of Personalized Medicine·Walter J LukiwYuhai Zhao
Sep 19, 2020·International Journal of Molecular Sciences·Mar PérezJesús Avila
Apr 17, 2020·Frontiers in Immunology·Harald HampelSimone Lista
Oct 9, 2020·Expert Review of Proteomics·Sonia MazzucchiFilippo Baldacci
Jan 5, 2021·PloS One·Gregory PennerUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Oct 5, 2019·Neurobiology of Aging·Nicola ToschiUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Feb 3, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Andrea VergalloUNKNOWN INSIGHT-preAD study group, and the Alzheimer Precision Medicine Initiative (APMI)
Nov 17, 2020·Frontiers in Neuroscience·Yuhai ZhaoWalter J Lukiw
Jan 29, 2021·Translational Psychiatry·Andrea VergalloUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Jun 21, 2020·Ageing Research Reviews·Pedro L ValenzuelaAlejandro Lucia
Mar 9, 2021·BMJ Neurology Open·Gianluigi Forloni
Sep 14, 2020·Neurobiology of Aging·Andrea VergalloUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
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Apr 30, 2021·Ageing Research Reviews·Harald HampelUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
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Nov 14, 2020·Alzheimer's Research & Therapy·Filippo BaldacciUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Jul 11, 2021·Life Sciences·Aryaman Girish Patwardhan, Sateesh Belemkar
Aug 14, 2021·Neurobiology of Aging·Pablo LemercierUNKNOWN INSIGHT-preAD study group and the Alzheimer Precision Medicine Initiative (APMI)
Aug 28, 2021·Diagnostics·Carlo FabrizioGiulia Sancesario
Jan 5, 2022·Journal of Neuropathology and Experimental Neurology·Mustafa N Shakir, Brittany N Dugger

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