The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar

Journal of the American College of Cardiology
Dimitrios A StakosKonstantinos Stellos

Abstract

Aging-related cellular and molecular processes including low-grade inflammation are major players in the pathogenesis of cardiovascular disease (CVD) and Alzheimer's disease (AD). Epidemiological studies report an independent interaction between the development of dementia and the incidence of CVD in several populations, suggesting the presence of overlapping molecular mechanisms. Accumulating experimental and clinical evidence suggests that amyloid-beta (Aβ) peptides may function as a link among aging, CVD, and AD. Aging-related vascular and cardiac deposition of Αβ induces tissue inflammation and organ dysfunction, both important components of the Alzheimer's disease amyloid hypothesis. In this review, the authors describe the determinants of Aβ metabolism, summarize the effects of Aβ on atherothrombosis and cardiac dysfunction, discuss the clinical value of Αβ1-40 in CVD prognosis and patient risk stratification, and present the therapeutic interventions that may alter Aβ metabolism in humans.

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Jan 1, 1991·Annals of the New York Academy of Sciences·W E Van NostrandD D Cunningham
Nov 25, 1998·British Journal of Haematology·A HenryR Cappai
May 20, 2000·Annals of the New York Academy of Sciences·H M WisniewskiJ Frackowiak
May 20, 2000·Annals of the New York Academy of Sciences·P BurgermeisterM Jucker
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·K NiwaC Iadecola
Nov 18, 2000·American Journal of Physiology. Cell Physiology·R GiriV K Kalra
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·K FassbenderT Hartmann
Jul 24, 2001·The International Journal of Neuropsychopharmacology·L T FriedhoffJ D Buxbaum
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K NiwaC Iadecola
Sep 20, 2002·The Journal of Biological Chemistry·Kathryn J MooreMason W Freeman
Apr 26, 2003·Dementia and Geriatric Cognitive Disorders·Magnus SjögrenKaj Blennow
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ranjit K GiriVijay K Kalra
Jun 11, 2003·The Journal of Experimental Medicine·Joseph B El KhouryAndrew D Luster
Jan 21, 2004·The Journal of Biological Chemistry·Cindy M Sondag, Colin K Combs
Mar 4, 2005·American Journal of Physiology. Cell Physiology·Ranjit K GiriVijay K Kalra
Mar 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D FryerDavid M Holtzman
Sep 13, 2005·The Journal of Biological Chemistry·Matthew L Hemming, Dennis J Selkoe
Apr 5, 2007·Annals of the New York Academy of Sciences·Tiziana CasoliCarlo Bertoni-Freddari
May 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Eszter HerczenikJan-Willem N Akkerman
Aug 10, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kun ZouMakoto Michikawa
Sep 21, 2007·Biochimica Et Biophysica Acta·Berta SchulzGerd Schmitz
Jan 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Laibaik ParkCostantino Iadecola
Mar 4, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ming-Yi ShenJoen-Rong Sheu
Jan 3, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Alex E RoherMarwan N Sabbagh
Jan 23, 2009·Journal of Alzheimer's Disease : JAD·Wei ZhaoGiulio M Pasinetti
Oct 10, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Shin-ichiro HayashiRyuichi Morishita
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susan A AustinColin K Combs

❮ Previous
Next ❯

Citations

May 16, 2020·3 Biotech·Maruti J Dhanavade, Kailas D Sonawane
Nov 26, 2020·International Journal of Molecular Sciences·Benedetta IzziAlessandro Gialluisi
Nov 5, 2020·Aging·Jose L CanteroRicardo S Osorio
Oct 10, 2020·European Journal of Internal Medicine·Aldostefano PorcariGianfranco Sinagra
Nov 29, 2020·Metabolism: Clinical and Experimental·Yanjun GuoChengfu Xu
Feb 6, 2021·Neurobiology of Aging·Maria Victoria Marca-YsabelMargaret A Pericak-Vance
Feb 14, 2021·Brain Sciences·Donovan A McGrowderRuby Alexander-Lindo
Feb 5, 2021·Frontiers in Cellular Neuroscience·Joe SteinmanZhong-Ping Feng
Jan 17, 2021·Journal of Clinical Lipidology·Lewis H Kuller
Dec 23, 2020·International Journal of Molecular Sciences·Giulia GagnoAneta Aleksova
Feb 20, 2021·Journal of the American College of Cardiology·Valentin Fuster
Feb 10, 2021·The Journal of Pharmacology and Experimental Therapeutics·Zizhen Si, Xidi Wang
Jun 18, 2021·PloS One·Koji FukuiMasahiro Kohno
Aug 15, 2021·Experimental Gerontology·Daniel H CraigheadDouglas R Seals
Aug 19, 2021·Metabolic Brain Disease·Ricardo Apátiga-PérezJosé Luna-Muñoz
Aug 22, 2021·Nature Metabolism·Mohammad R IslamChristiane D Wrann

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Related Papers

Current Opinion in Psychiatry
Satoshi Saito, Masafumi Ihara
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Joel N Buxbaum
Journal of Alzheimer's Parkinsonism & Dementia
Shaoxun WangFan Fan
© 2021 Meta ULC. All rights reserved