The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials

Neurology
P M DoraiswamyB Gulanski

Abstract

The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) is used as an efficacy measure in clinical drug trials of Alzheimer's disease (AD). We used data from 1,648 AD participants in two identical 26-week multicenter drug trials to examine the distribution of baseline ADAS-Cog scores in relation to selected demographic and clinical variables, Mini-Mental State Exam (MMSE), Global Deterioration Scale (GDS), and Geriatric Evaluation by Relative's Rating Instrument (GERRI) scores. At baseline, the mean (+/-SD) MMSE score was 18 +/- 4, the ADAS-Cog score was 28 +/- 11, and most subjects were in GDS stage 4 or 5. The ADAS-Cog score was statistically significantly correlated with MMSE (R = -0.76, p < 0.0001) and GERRI (R = 0.40, p < 0.0001) total scores. Correlations among the ADAS-Cog items ranged from 0.19 to 0.59 and all were statistically significant (p < 0.0001). In a multiple regression model, younger age, male gender, older age at onset of dementia, use of concurrent estrogen, and use of concurrent anti-inflammatory agents were statistically significantly associated with superior cognitive performance. We also present data on the distribution of ADAS-Cog scores in relation to subjects' age, level of educa...Continue Reading

Citations

May 25, 2005·European Journal of Clinical Pharmacology·Roberto RaschettiNicola Vanacore
Jul 13, 2006·European Journal of Clinical Pharmacology·Emmanuel KrupkaMarie-Christine Perault
Aug 4, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Andrew J Levine, Matthew Battista
Dec 14, 1999·Journal of the Neurological Sciences·S A Rudnicki
Jul 16, 2003·Clinical Therapeutics·Kristen Migliaccio-WalleUNKNOWN AHEAD Study Group
Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·A MaggiP Ciana
Jun 19, 2002·Alzheimer Disease and Associated Disorders·L D Altstiel
Dec 7, 2002·Alzheimer Disease and Associated Disorders·Joy L TaylorJerome A Yesavage
Sep 27, 2003·Alzheimer Disease and Associated Disorders·Steven H Ferris, Bing Yan
Mar 16, 2007·Dementia and Geriatric Cognitive Disorders·Matthias W RiepeIbrahim Gunay
Aug 18, 2012·BMC Neurology·Astrid M HooghiemstraErik J A Scherder
Apr 1, 2008·Annals of Indian Academy of Neurology·R Mathew, P S Mathuranath
Jun 4, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Victor W Henderson
Jan 15, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael S RafiiRaymond T Bartus
May 2, 2007·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Andrew Kirk
May 2, 2007·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Kiran Rabheru
Nov 1, 2007·Women's Health·Amr BilleciG Agnelli
Apr 24, 2013·Journal of Clinical Psychopharmacology·Yuan-Han YangSu-Hwei Chen
Sep 11, 2002·International Journal of Geriatric Psychiatry·J C YounJ I Woo
Aug 13, 2002·Expert Opinion on Biological Therapy·Jamie L Eberling
Mar 5, 2004·Expert Opinion on Pharmacotherapy·Victor W Henderson
May 23, 2012·Climacteric : the Journal of the International Menopause Society·P M Maki, V W Henderson
Sep 3, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kaori ItoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 14, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kaori ItoUNKNOWN Alzheimer's Disease Working Group
Feb 19, 2008·La Presse médicale·Olivier Saint JeanCéline Lazarovici
Jan 18, 2014·Frontiers in Neuroendocrinology·Rena Li, Meharvan Singh
Jun 11, 2011·Journal of Clinical Pharmacology·Mahesh N SamtaniUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 29, 2014·Statistics in Medicine·Koko AsakuraTakashi Sozu
Jul 6, 2005·Neurobiology of Aging·Monica Garcia-AllozaMaría J Ramirez
Mar 25, 2014·Journal of the Neurological Sciences·David M ErlangerJohn Deluca
Jun 27, 2008·Yonsei Medical Journal·Byung Hwa JungSang Wook Bai
Jun 18, 2016·Neuroscience Journal·Emanuela ZagniDelia Colombo
Dec 17, 2009·Neurobiology of Aging·Barbara B SherwinZiad Nasreddine
Oct 11, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R R SchultzP H Bertolucci
Aug 14, 1999·Journal of Geriatric Psychiatry and Neurology·B M McLendon, P M Doraiswamy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.