The Amazonian fruit Byrsonima crassifolia effectively scavenges reactive oxygen and nitrogen species and protects human erythrocytes against oxidative damage

Food Research International
Lilian R B MariuttiAdriana Zerlotti Mercadante

Abstract

A hydrophilic extract of murici (Byrsonima crassifolia), a fruit native to the North and Northeast regions of Brazil, was evaluated in relation to its phenolic composition and in vitro antioxidant potential against some physiologically relevant reactive oxygen and nitrogen species. Additionally, the protective effect of murici extract against peroxyl radical (ROO)-induced toxicity to human erythrocytes was also determined. The major phenolic compound, determined by HPLC-DAD-MSn, was quercetin (2.72±0.35μg/mL). The extract was able to scavenge ROO (0.30±0.04μmoltroloxequivalent/mg), hypochlorous acid (IC50=10.0±0.1μg/mL), hydroxyl radical (IC50=7±1μg/mL) and peroxynitrite anion (IC50=21.0±0.6μg/mL and 17.0±1.6μg/mL, respectively, in absence and presence of NaHCO3). Human erythrocytes were subjected to oxidative damage, but murici extract was not able to inhibit hemolysis, even at the highest tested concentration. On the other hand, the extract inhibited hemoglobin oxidation (IC50=271±44μg/mL), lipid peroxidation (1000μg/mL) by 48±5%, depletion of glutathione (100μg/mL) by 49±2% and formation of its oxidized form (100μg/mL) by 96±4%.

Citations

Nov 15, 2018·Journal of Separation Science·Karina FraigeVanderlan da Silva Bolzani
Oct 11, 2017·Phytochemical Analysis : PCA·Karina FraigeVanderlan S Bolzani
Nov 29, 2016·Food & Function·Daniele Bobrowski RodriguesAdriana Zerlotti Mercadante
Nov 9, 2019·Biomolecules·Vanessa Rosse de SouzaAnderson Junger Teodoro
Jun 21, 2015·European Journal of Nutrition·Maryam Abimbola MikailMohammad Noor Adros Yahya
Apr 30, 2019·Nutritional Neuroscience·Mariana Séfora Bezerra SousaAngela Amancio-Dos-Santos
Jan 15, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adriana AnicetoAnderson Junger Teodoro
Nov 12, 2020·International Journal of Molecular Sciences·Andrea Gómez-MaqueoJorge Welti-Chanes
Jan 30, 2021·Food Research International·Lais Marinho AguiarCinthia Baú Betim Cazarin
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joselin AguiarJosé S Câmara
Aug 6, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Andréia Limana TambaraCristiane Casagrande Denardin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.