The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Muhammed Sedat SakatYavuz Selim Saglam

Abstract

Berberine and coenzyme Q10 (CoQ10) are agents with anti-inflammatory and antioxidant characteristics. The purpose of this study was to investigate the effectiveness of berberine and CoQ10 on allergic rhinitis. This study involved 30 Sprague-Dawley rats, and allergic rhinitis model was established with induction of ovalbumin. Rats were randomized into five groups. The first represented the control group, in which no allergy was established. The second represented the allergy group, in which allergy was induced but no treatment was given. In the remaining three groups, following induction of allergy, desloratadine at a dose of 10 mg/kg was given to Group 3, 100 mg/kg dose of berberine to Group 4, and 20 mg/kg dose of CoQ10 to Group 5. Nasal symptom scores, and plasma immunoglobulin-E, interleukin (IL)-4, IL-13, malondialdehyde (MDA) and nitric oxide (NO) levels were examined at the end of the study. Rats' nasal tissues were also subjected to histopathological immunohistochemical examination. Nasal symptom scores, and plasma immunoglobulin-E, IL-4, IL-13, MDA and NO levels increased significantly in rats with induced allergic rhinitis. Berberine and CoQ10 significantly reduced these elevated levels. CoQ10 was also found as effecti...Continue Reading

References

Aug 1, 1966·Analytical Biochemistry·Z A PlacerB C Johnson
Apr 12, 2001·Allergy·L Yman
Jul 29, 2006·BioFactors·Anna GvozdjákováFrantis Ek Gazdík
Sep 23, 2009·The Journal of Experimental Medicine·Raffi TachdjianTalal A Chatila
Sep 8, 2010·The Journal of Allergy and Clinical Immunology·Jan L BrozekUNKNOWN Grading of Recommendations Assessment, Development and Evaluation Working Group
Jan 11, 2014·The Laryngoscope·Hille SuojalehtoElina Toskala
Jun 17, 2014·Journal of Diabetes and Metabolic Disorders·Md Ashraful Alam, Md Mahbubur Rahman
May 14, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Zhenghao LiChengde Li
May 25, 2016·American Journal of Rhinology & Allergy·Seckin UlusoyOzcan Erel
Aug 23, 2016·Primary Care·Hasan A Kakli, Timothy D Riley
May 12, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mustafa SagitMehmet Yasar
Oct 27, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Erol SenturkIlker Kocak
Nov 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saeed MehrzadiMehdi Goudarzi
Jan 31, 2018·In Vitro Cellular & Developmental Biology. Animal·Johnny L CarsonMilan J Hazucha
Feb 21, 2018·Frontiers in Physiology·Juan D Hernández-CamachoPlácido Navas

❮ Previous
Next ❯

Citations

Oct 18, 2019·International Forum of Allergy & Rhinology·Jin-Mei XuePing-Chang Yang
Nov 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuilian FuTie Hong
Mar 28, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Abdulkadir ŞahinSefa Kucukler
May 10, 2021·Auris, Nasus, Larynx·Asli Cakir CetinYesim Tuncok

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Erol SenturkIlker Kocak
© 2022 Meta ULC. All rights reserved