The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytes

PloS One
Solee Jin, Mi-Young Lee

Abstract

In this study, we investigated the anti-microbial, anti-inflammatory, and anti-lipogenic effects of hemp (Cannabis sativa L.) seed hexane extracts, focusing on the Propionibacterium acnes-triggered inflammation and lipogenesis. Hemp seed hexane extracts (HSHE) showed anti-microbial activity against P. acnes. The expression of iNOS, COX-2, and the subsequent production of nitric oxide and prostaglandin increased after infection of P. acnes in HaCaT cells, however, upon treating with HSHE, their expressions were reduced. P. acnes-induced expressions of IL-1β and IL-8 were also reduced. HSHE exerted anti-inflammatory effects by regulating NF-κB and MAPKs signaling and blunting the translocation of p-NF-κB to the nucleus in P. acnes-stimulated HaCaT cells. Moreover, P. acnes-induced phosphorylation of ERK and JNK, and their downstream targets c-Fos and c-Jun, was also inhibited by HSHE. In addition, the transactivation of AP-1 induced by P. acnes infection was also downregulated by HSHE. Notably, HSHE regulated inflammation and lipid biosynthesis via regulating AMPK and AKT/FoxO1 signaling in IGF-1-induced inflammation and lipogenesis of sebocytes. In addition, HSHE inhibited 5-lipoxygenase level and P. acnes-induced MMP-9 activity...Continue Reading

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Citations

Jul 17, 2020·Antibiotics·John A KarasTony Velkov
Dec 19, 2020·Clinical, Cosmetic and Investigational Dermatology·Sudhir M BaswanNathan Stern
Jan 1, 2021·Cannabis and Cannabinoid Research·Melissa A Nickles, Peter A Lio
Jan 29, 2021·Biomolecules·Melita LončarićMaja Molnar
Apr 15, 2021·Planta medica·Giulia MartinelliEnrico Sangiovanni

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Methods Mentioned

BETA
ELISA
transfection
nuclear translocation
confocal microscopy

Software Mentioned

Statistical Package for Social Sciences ( SPSS
ImageJ

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