PMID: 8971793Nov 22, 1996Paper

The amino-terminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients

Neuroscience Letters
Haruhiko AkiyamaP L McGeer

Abstract

We have investigated the cerebral cortex of Alzheimer's disease in which small infarcts are found on postmortem neuropathological examination. In areas that have been subjected to recent ischemia, immunohistochemical staining for amyloid beta-protein (A beta) is much less intense than in the non-ischemic surround. However, the infiltrating brain macrophages contain granules immunopositive for C-terminal fragments of A beta. The immunohistochemical profile indicates that A beta in these granules lacks epitopes in the N-terminal fragments. These data suggest that appropriately stimulated macrophages can phagocytose A beta deposits and that digestion of the N-terminal region is an early consequence of this phagocytosis.

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Citations

Apr 27, 2005·Brain Research. Brain Research Reviews·Lap HoGiulio Maria Pasinetti
Oct 4, 2000·Neurobiology of Aging· Colle M-AC Duykaerts
Jun 13, 2000·Alzheimer Disease and Associated Disorders·H AkiyamaK Ikeda
Feb 25, 2011·Current Alzheimer Research·K Rezai-ZadehT Town
Jul 11, 2012·International Journal of Alzheimer's Disease·Tara M Weitz, Terrence Town
Aug 9, 2015·Brain, Behavior, and Immunity·Ayman ElAli, Serge Rivest
Jan 24, 2017·Phytotherapy Research : PTR·Jin Gyu ChoiMyung Sook Oh
Nov 17, 2010·Toxicologic Pathology·Julia Kofler, Clayton A Wiley
Feb 5, 2004·Nature Medicine·Haruhiko Akiyama, Patrick L McGeer
Oct 29, 2004·The American Journal of Pathology·Dominique LanguiCharles Duyckaerts

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