The amnion muscle combined graft (AMCG) conduits in nerves repair: an anatomical and experimental study on a rat model

Journal of Materials Science. Materials in Medicine
Andrea MarchesiniM Riccio

Abstract

The amnion muscle combined graft (AMCG) conduits showed good clinical results in peripheral nerves gap repair. It combines the human amniotic membrane with autologous skeletal muscle fibres. These results seem attributable to the biological characteristics of human amniotic membrane: Pluripotency, anti-inflammatory and low immunogenicity.We here evaluate the final outcome of nerve regeneration morphologically and functionally, across the AMCG compared to nerve autograft. Fourteen Wistar rats were divided into two groups: In Group A, including 6 rats, the left forelimb was treated performing a 1.5 cm length gap on median nerve that was then reconstructed with a reverse autograft. In Group B, including 8 rats, the gap was reconstructed with AMCG. Functional results were evaluated at 30, 60 and 90 days performing grasping tests. Morphological and stereological analyses were performed at T90 using high-resolution light microscopy and design-based stereology. The AMCG conduits revealed nerve fibres regeneration and functional recovery. Functional recovery was observed in both groups with AMCG conduits group showing lower values and a regeneration of median nerves with more myelinated fibres with the same axon size, but thinner myeli...Continue Reading

References

Sep 1, 1987·The Journal of Hand Surgery·F W BoraA J Sumner
Jan 1, 1989·Progress in Neurobiology·R D FieldsM H Ellisman
Feb 20, 1989·Brain Research·R F ValentiniP Aebischer
Apr 1, 1985·Annals of Plastic Surgery·S E MackinnonD A Hunter
Aug 1, 1984·Plastic and Reconstructive Surgery·B R SeckelR L Sidman
May 20, 1998·Trends in Biotechnology·C A Heath, G E Rutkowski
Mar 13, 2003·Journal of Reconstructive Microsurgery·S GeunaI Perroteau
Jun 29, 2005·The Journal of Comparative Neurology·Stefania RaimondoStefano Geuna
Nov 8, 2007·Journal of Pharmacological Sciences·Ayaka TodaToshio Nikaido
Oct 19, 2010·Progress in Neurobiology·Ronald DeumensGary A Brook
Oct 30, 2013·Cell and Tissue Banking·Asmita BanerjeeSusanne Wolbank
Mar 13, 2014·Journal of Brachial Plexus and Peripheral Nerve Injury·Stefano GeunaBruno Battiston
Apr 20, 2014·Journal of Applied Biomaterials & Functional Materials·Antonio MerolliFu-Zhai Cui

❮ Previous
Next ❯

Citations

Aug 10, 2019·Neural Regeneration Research·Zhong-Yuan ZhangChang-Yin Yu
Jun 12, 2019·Hand Surgery and Rehabilitation·M BourgeoisF Gindraux
Jun 3, 2021·Membranes·Mathilde FénelonFlorelle Gindraux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.