PMID: 6411491Aug 22, 1983Paper

The amount and nature of glutathione transferases in rat liver microsomes determined by immunochemical methods

FEBS Letters
R MorgensternJ W DePierre

Abstract

The amount and nature of glutathione transferases in rat liver microsomes were determined using immunological techniques. It was shown that cytosolic glutathione transferase subunits A plus C, and B plus L were present at levels of 2.4 +/- 0.6 and 1.5 +/- 0.1 microgram/mg microsomal protein, respectively. These levels are 10-times higher than those for non-specific binding of cytosolic components judging from the distribution of lactate dehydrogenase, a cytosolic marker. The possibility that a portion of these glutathione transferases is functionally localized on the endoplasmic reticulum is discussed. A previously described microsomal glutathione transferase which is distinct from the cytosolic enzymes is present in an amount of 31 +/- 6 micrograms/mg microsomal protein.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Apr 13, 1979·Biochemical and Biophysical Research Communications·R MorgensternL Ernster
Aug 1, 1980·Biochimica Et Biophysica Acta·C GuthenbergB Mannervik
Feb 1, 1980·European Journal of Biochemistry·R MorgensternL Ernster
Jan 1, 1982·Acta Chemica Scandinavica. Series B: Organic Chemistry and Biochemistry·R Morgenstern, L Dock
Aug 14, 1981·Biochemical and Biophysical Research Communications·C C ReddyE J Massaro
Jan 1, 1980·Hoppe-Seyler's Zeitschrift für physiologische Chemie·P Kraus

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Citations

Jul 31, 1995·Biochemical Pharmacology·G Lundqvist, R Morgenstern
Feb 16, 1994·Biochimica Et Biophysica Acta·C AnderssonR Morgenstern
May 15, 1994·European Journal of Biochemistry·M E HorbachT P Akerboom
Aug 24, 2010·Free Radical Biology & Medicine·Katarina JohanssonRalf Morgenstern
Oct 24, 1991·Biochemical Pharmacology·L J ShoreG B Odell
Nov 16, 2011·The Biochemical Journal·Chonticha SaisawangAlbert J Ketterman
Oct 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B Ketterer
Mar 1, 1988·Archives internationales de physiologie et de biochimie·P J Dierickx
Jan 1, 1987·Free Radical Research Communications·K H TanB Ketterer
May 15, 1991·Archives of Biochemistry and Biophysics·G R HaenenA Bast
May 25, 2006·The Journal of Pharmacology and Experimental Therapeutics·Yanbin Ji, Brian M Bennett
Sep 14, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rosanna RinaldiRalf Morgenstern
Sep 20, 2017·Ecotoxicology and Environmental Safety·Chaitali P LabadeVaijayanti A Tamhane

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