The amphetamine-induced inhibition of dopamine biosynthesis in rat striatum

European Journal of Pharmacology
J P HudickA Lajtha

Abstract

The dopamine biosynthetic machinery of intact synaptosomes of rat striatum showed a 5-fold increase in development from 3-day-old neonates to adults, and it was fully developed between 2-3 weeks after birth. Concurring with this development was the appearance 2 weeks after birth of a regulatory mechanism(s) through which amphetamine in vivo induced an inhibition of dopamine biosynthesis. The inhibition was not appreciably reversed when haloperidol, in addition to amphetamine, was administered.

References

Feb 1, 1975·European Journal of Pharmacology·R Kuczenski, D S Segal
Feb 1, 1975·European Journal of Pharmacology·P A Shore, R L Dorris
Sep 1, 1973·The Journal of Pharmacy and Pharmacology·J E Harris, R J Baldessarini
Jul 1, 1974·Journal of Neurochemistry·R L Patrick, J D Barchas

Citations

May 31, 1978·Psychopharmacology·K R Carlson, J Almasi
Jun 1, 1980·Journal of Neurochemistry·R L Patrick, M T Rendel
Aug 1, 1977·The Journal of Pharmacy and Pharmacology·C Braestrup

Related Concepts

Senility
Metazoa
Lentiform Nucleus Structure
Depression, Chemical
Oxydess
Intropin
Haldol
Synaptosomes
Tyrosine 3-Monooxygenase
Rats, Laboratory

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