The amphioxus T-box gene, AmphiTbx15/18/22, illuminates the origins of chordate segmentation

Evolution & Development
Laura Beaster-JonesLinda Z Holland

Abstract

Amphioxus and vertebrates are the only deuterostomes to exhibit unequivocal somitic segmentation. The relative simplicity of the amphioxus genome makes it a favorable organism for elucidating the basic genetic network required for chordate somite development. Here we describe the developmental expression of the somite marker, AmphiTbx15/18/22, which is first expressed at the mid-gastrula stage in dorsolateral mesendoderm. At the early neurula stage, expression is detected in the first three pairs of developing somites. By the mid-neurula stage, expression is downregulated in anterior somites, and only detected in the penultimate somite primordia. In early larvae, the gene is expressed in nascent somites before they pinch off from the posterior archenteron (tail bud). Integrating functional, phylogenetic and expression data from a variety of triploblast organisms, we have reconstructed the evolutionary history of the Tbx15/18/22 subfamily. This analysis suggests that the Tbx15/18/22 gene may have played a role in patterning somites in the last common ancestor of all chordates, a role that was later conserved by its descendents following gene duplications within the vertebrate lineage. Furthermore, the comparison of expression do...Continue Reading

References

Apr 1, 1994·Anatomy and Embryology·P P Tam, P A Trainor
Aug 10, 2000·Nature Genetics·Y TakahashiY Saga
Dec 19, 2000·Mechanisms of Development·F KrausA Kispert
Feb 22, 2001·Developmental Biology·K Degenhardt, D A Sassoon
May 16, 2001·International Review of Cytology·V E Papaioannou
Jun 29, 2001·Mechanisms of Development·V E PrinceT F Vogt
Nov 1, 2001·Annual Review of Cell and Developmental Biology·O Pourquié
Nov 21, 2001·Nature Reviews. Genetics·Y Saga, H Takeda
Apr 6, 2002·Bioinformatics·Heiko A SchmidtArndt von Haeseler
Jul 16, 2002·Systematic Biology·B J SwallaJ R Garey
Aug 15, 2002·Mechanisms of Development·Gerrit BegemannPhillip W Ingham
Aug 20, 2002·Development Genes and Evolution·Jean-Michel Gibert
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jeffrey O BushRulang Jiang
Nov 9, 2002·Development Genes and Evolution·Takashi AkanumaHiroki Nishida
Mar 15, 2003·Developmental Cell·Alexander AulehlaBernhard G Herrmann
Apr 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexander HerrUlrike A Nuber
Apr 2, 2003·Human Molecular Genetics·Elizabeth A Packham, J David Brook
Aug 21, 2003·Development Genes and Evolution·Françoise Mazet, Sebastian M Shimeld
Oct 17, 2003·Development·Carolina MinguillónJordi Garcia-Fernàndez
Dec 31, 2003·Developmental Biology·Padmashree C G RidaYun Jin Jiang
Jan 23, 2004·PLoS Biology·Sophie I CandilleGregory S Barsh
Apr 6, 2004·Developmental Biology·Mikiko Tanaka, Cheryll Tickle
Jul 16, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Naohito TakatoriHiroki Takahashi
Jul 17, 2004·Development Genes and Evolution·Bénédicte Haenig, Andreas Kispert
Sep 17, 2004·Development Genes and Evolution·Navin R MahadevanJeremy J Gibson-Brown
Dec 4, 2004·Methods in Cell Biology·Linda Z Holland, Ju-Ka Yu
Jan 18, 2005·Mechanisms of Development·Manvendra K SinghAndreas Kispert
Feb 11, 2005·Molecular Biology and Evolution·Hervé PhilippeHenner Brinkmann

❮ Previous
Next ❯

Citations

Oct 25, 2008·Development Genes and Evolution·Laura Beaster-JonesLinda Z Holland
Nov 21, 2007·Nature Reviews. Neuroscience·Trevor D LambEdward N Pugh
Nov 1, 2008·Integrative and Comparative Biology·Shigeru Kuratani
Nov 1, 2008·Integrative and Comparative Biology·Linda Z HollandEdwin Gilland
Dec 28, 2010·Gene Expression Patterns : GEP·Mohamed R BelgacemStephanie Bertrand
Feb 15, 2007·Genesis : the Journal of Genetics and Development·Stacy L K RasmussenNicholas D Holland
Sep 6, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Demian Koop, Linda Z Holland
May 9, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Scott A Holley
May 16, 2007·Evolution & Development·Atsuko YamadaShin Tochinai
Nov 13, 2008·Current Biology : CB·Seth S Blair
Jun 23, 2007·The Journal of Biological Chemistry·Henner F FarinAndreas Kispert
May 26, 2011·Development·Ramkumar SambasivanShahragim Tajbakhsh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.