The amygdala is part of the behavioural reinforcement system modulating long-term potentiation in rat hippocampus

Neuroscience
W Almaguer-MelianJorge A Bergado

Abstract

Long-term potentiation (LTP) in the dentate gyrus can be modulated and prolonged by emotional/motivational influences when concurrently activated. A similar effect on LTP can be obtained by stimulating the amygdala, suggesting that this limbic structure might be part of the neural system involved in behavioural reinforcement. To confirm this we have performed a series of experiments in which the basolateral amygdala was either temporary inactivated by injection of lidocaine or permanently lesioned electrolytically. Both manipulations completely blocked the reinforcing effect of a motivational stimulus (drinking after 24-h deprivation) on LTP at the perforant pathway-dentate gyrus synapses, whilst leaving intact the non-reinforced potentiation. These results demonstrate that the basolateral amygdala is a key structure within the system involved in the modulatory interaction between the affective status of the animal and the mechanisms of functional plasticity.

References

May 1, 1995·Physiology & Behavior·T SeidenbecherK G Reymann
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·M G PackardJ L McGaugh
Feb 6, 1997·Nature·U Frey, R G Morris
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·T SeidenbecherD Balschun
Feb 1, 1997·Behavioural Brain Research·J L McGaugh, L Cahill
Jan 24, 2002·Neurobiology of Aging·William AlmaguerJorge A Bergado

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Citations

Feb 25, 2005·Behavioral Neuroscience·Lesley A Schimanski, Peter V Nguyen
May 25, 2006·Behavioral Neuroscience·Diana B PadlubnayaThomas H Brown
Nov 30, 2011·Behavioral Neuroscience·Benno Roozendaal, James L McGaugh
Jan 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·William Almaguer-MelianJulietta U Frey
Dec 5, 2006·Learning & Memory·Colin M O'CarrollRichard G M Morris
Mar 19, 2005·Learning & Memory·Shukhrat UzakovVolker Korz
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shoki OkudaJames L McGaugh
Mar 26, 2011·Progress in Neurobiology·Jorge A BergadoGal Richter-Levin
Jul 30, 2010·Physiology & Behavior·W Almaguer-MelianJ U Frey
Oct 6, 2009·Neurobiology of Learning and Memory·Emmanuel GalliotGregory Pourié
Mar 4, 2014·Neurobiology of Learning and Memory·Erno J HermansBenno Roozendaal
Jan 15, 2008·Neuropsychologia·Bianca C WittmannEmrah Düzel
Jan 15, 2005·Biochemical and Biophysical Research Communications·W Almaguer-MelianJ Bergado
Aug 7, 2009·Stress : the International Journal on the Biology of Stress·Phillip R ZoladzDavid M Diamond
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·Daymara Mercerón-MartínezAdrian G Palacios
Jul 25, 2021·Neurobiology of Learning and Memory·Rafael RoeslerChrista K McIntyre

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