PMID: 6172175Jan 1, 1982Paper

The amylase-to-creatinine clearance ratio--a non-specific response to acute illness?

The British Journal of Surgery
M J McMahonE H Cooper

Abstract

It was felt that the apparent specificity of the amylase-to-creatine clearance ratio (ACCR) in several previous studies of pancreatitis might reflect a failure to utilize adequately ill control subjects. The ACCR and the renal clearances of beta 2-microglobulin (B2-m), similarly related to creatinine (BCCR) as well as the urinary concentration of albumin, were compared in 27 patients with acute pancreatitis, 8 with a perforated peptic ulcer and 7 with mild biliary colic, during the first 5 days in hospital. Acute pancreatitis was graded as mild (6), moderate (14) or severe (7), using a combination of clinical data, diagnostic peritoneal lavage and multiple criteria. Further assessment of the severity of the acute illness was obtained from measurement of C-reactive protein (C-RP). Lowest C-RP levels were found in the patients with mild pancreatitis and biliary colic, and highest levels in the patients with severe pancreatitis and perforated ulcer (P less than 0.002). Similarly, ACCR and BCCR levels were significantly lower in the two mild groups than in the two severe ones (P less than 0.01 and less than 0.002 respectively), although plasma amylase was raised only in patients with pancreatitis and plasma B2-m was similar in all ...Continue Reading

References

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Citations

Jun 1, 1996·European Journal of Pediatrics·C Y YeungJ C Sheu
Feb 1, 1997·World Journal of Surgery·J H Ranson
Sep 6, 1984·The New England Journal of Medicine·A R Moossa
Feb 1, 1984·Journal of Clinical Pathology·A D MayerE H Cooper
Mar 1, 1984·The Journal of Surgical Research·K V CrocketS N Joffe
Jul 19, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ahmed Z Al-Bahrani, Basil J Ammori
Aug 1, 1987·Scandinavian Journal of Gastroenterology·H J ThomsonW G Brydon
Dec 1, 1989·The British Journal of Surgery·P A ClavienA R Moossa
Aug 24, 1999·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·C DervenisI Modlin

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