PMID: 9192870Jun 1, 1997Paper

The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals

Genes & Development
N de VettenR Koes

Abstract

In petunia flowers, the loci an1, an2, and an11 control the pigmentation of the flower by stimulating the transcription of anthocyanin biosynthetic genes. The an1 and an2 locus were recently cloned and encode a basic helix-loop-helix (bHLH) and MYB-domain transcriptional activator, respectively. Here, we report the isolation of the an11 locus by transposon tagging. RNA gel blot experiments show that an11 is expressed independently from an1 and an2 throughout plant development, as well as in tissues that do not express the anthocyanin pathway. It encodes a novel WD-repeat protein that is highly conserved even in species that do not produce anthocyanins such as yeast, nematodes, and mammals. The observation that the human an11 homolog partially complements the an11 petunia mutant in transient assays shows that sequence similarity reflects functional conservation. Overexpression of an2 in an11- petals restored the activity of a structural anthocyanin gene in transient assays, indicating that AN11 acts upstream of AN2. Cell fractionation experiments show that the bulk of the AN11 protein is localized in the cytoplasm. Taken together, this indicates that AN11 is a cytoplasmic component of a conserved signal transduction cascade that...Continue Reading

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Citations

Dec 8, 2005·Molecular Genetics and Genomics : MGG·Antonio G LalusinTatsuhito Fujimura
Aug 29, 2003·Phytochemistry·M A Susan MarlesMargaret Y Gruber
Mar 6, 1999·Current Opinion in Plant Biology·B Weisshaar, G I Jenkins
Mar 20, 2003·Cell Research·Fang LinHong Wei Xue
Jul 22, 1998·The Plant Journal : for Cell and Molecular Biology·J BernhardtU Wienand
Jan 9, 1999·The Plant Journal : for Cell and Molecular Biology·H FujiwaraT Kusumi
Oct 3, 1999·The Plant Journal : for Cell and Molecular Biology·M DevicM Delseny
Nov 28, 2001·The Plant Journal : for Cell and Molecular Biology·A AharoniA P O'Connell
Feb 1, 2011·Journal of Experimental Botany·Imène HichriVirginie Lauvergeat
Apr 5, 2005·The Plant Cell·Julian C VerdonkRobert C Schuurink
Feb 2, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ahmed F YousefJoe S Mymryk
Sep 25, 2003·Annual Review of Plant Biology·John C LarkinJohn Schiefelbein
May 4, 2006·Annual Review of Plant Biology·Erich Grotewold
May 4, 2006·Annual Review of Plant Biology·Loïc LepiniecMichel Caboche

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