PMID: 2501044May 1, 1989Paper

The ANA profile: quality and cost-effective laboratory utilization

Cleveland Clinic Journal of Medicine
J D CloughR Valenzuela

Abstract

The ANA Profile was introduced in 1981 and computerized in 1984 as a means of facilitating follow-up testing for specific antibodies (anti-nDNA, anti-Sm, anti-RNP, anti-La/SS-B) in sera found to contain antinuclear antibodies (ANA). A second purpose was to avoid unnecessary specific antibody testing on negative or low-titer sera. This study was done to evaluate the effectiveness of the computerized ANA Profile reporting system in accomplishing these purposes. The authors compared ordering practices during two two-week periods, one in 1984 and a second in 1988, and found that follow-up testing on positive sera had improved from 27% to 70% with a reduction in unnecessary specific-antibody testing of ANA-negative or low-titer sera from 11% to 1.6%. In 1988 dollars, the annual savings from eliminating unnecessary testing was calculated to be $12,000. The ANA Profile has been partially successful in accomplishing the purposes for which it was introduced.

Citations

Jun 4, 2002·Best Practice & Research. Clinical Rheumatology·Peter J Maddison
Aug 1, 1997·Immunopharmacology and Immunotoxicology·D W Hunt, J G Levy
Sep 15, 1998·Immunopharmacology and Immunotoxicology·D W HuntJ G Levy

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