The Anabaena sp. strain PCC 7120 gene all2874 encodes a diguanylate cyclase and is required for normal heterocyst development under high-light growth conditions.

Journal of Bacteriology
M Ramona Neunuebel, James W Golden

Abstract

The genome of the heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120 harbors 14 genes containing a GGDEF diguanylate cyclase domain. We found that inactivation of one of these genes, all2874, caused abnormal heterocyst development. The all2874 mutant showed a pronounced reduction in heterocyst frequency during diazotrophic growth and reduced vegetative cell size compared to the wild type. The severity of the mutant phenotype varied with light intensity; at high light intensity, the mutant phenotype was accentuated, whereas at low light intensity the phenotype was similar to wild type. Under high-light growth conditions, the initial heterocyst frequency and pattern for the all2874 mutant were normal, but within 4 days following nitrogen step-down, many intervals between heterocysts increased to as many as 200 vegetative cells, whereas in the wild type the intervals were less than 25 vegetative cells. Filaments containing these unusually long vegetative cell intervals between heterocysts also contained intervals of normal length. An all2874 mutant strain carrying a P(patS)-gfp transcriptional reporter fusion failed to show normal upregulation of the reporter, which indicates that the decrease in heterocyst frequency i...Continue Reading

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Citations

Jan 30, 2013·Nucleic Acids Research·Valentina StelitanoFrancesca Cutruzzolà
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Krithika KumarJames W Golden
Aug 23, 2011·Journal of Bacteriology·Erik PetersenGary Splitter
Dec 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Hermann BotheWilliam E Newton
Mar 9, 2013·Microbiology and Molecular Biology Reviews : MMBR·Ute RömlingMark Gomelsky
Jun 16, 2015·Frontiers in Microbiology·Beronda L Montgomery
Aug 18, 2012·Trends in Microbiology·Alicia M Muro-Pastor, Wolfgang R Hess
Mar 17, 2009·BMC Microbiology·Marie HolmqvistPeter Lindblad
Mar 31, 2015·PLoS Computational Biology·Alejandro Torres-SánchezFernando Falo
Jan 5, 2014·Physical Biology·Aidan I Brown, Andrew D Rutenberg
Oct 19, 2013·IUBMB Life·Pauline Schaap
Jul 26, 2014·The Journal of Biological Chemistry·Gen EnomotoMasahiko Ikeuchi
Dec 21, 2021·Frontiers in Microbiology·Min HuangCheng-Cai Zhang

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