The analgesic effect of botulinum-toxin A on postwhiplash neck pain

The Clinical Journal of Pain
Clara BrakerElon Eisenberg

Abstract

The effectiveness of botulinum neurotoxin type A (BTXA) injections in relieving the neck pain and reduced motion that evolve after whiplash injury (WI) has been controversial. To test the long-term efficacy of a tender point injection of BTXA in relieving neck pain in patients with WI. Twenty patients with cervical myofascial pain, 2 to 48 weeks after WI, were randomly assigned to receive either 200 U of BTXA or placebo at 4 tender points and were seen during the follow-ups 3, 6, 9, 12, and 24 weeks after the injections. Outcome measures included the intensity of pain as evaluated by a 10-cm Visual Analog Scale (VAS) and a 5-point Verbal Rating Scale (VRS), quality of life as evaluated by the SF-36 questionnaire, treatment efficacy as per the global assessment of the physician and patient, intensity of pain in response to mechanical pressure, range of cervical motion, and use of other therapies and their adverse effects. A time-dependent improvement in all the parameters was found in both groups, which was consistently larger in the BTXA-treated group, but mostly not at a significant level. Significant differences between the groups were found only in the percentages of patients who achieved 50% or more of reduction in intensit...Continue Reading

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Citations

Jul 11, 2012·Current Pain and Headache Reports·Robert Gerwin
Oct 9, 2012·The Clinical Journal of Pain·Mark P JensenErrol M Gould
Jan 9, 2010·Disability and Rehabilitation·Yun Hyung KoogByung-Il Min
Oct 26, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Thiru Mandyam AnnaswamyDavid Berbrayer
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·José M ClimentFrancisco Martin-Del-Rosario
May 23, 2015·The Cochrane Database of Systematic Reviews·Pierre LangevinTed Haines
May 23, 2015·The Cochrane Database of Systematic Reviews·Paul Michael J PelosoUNKNOWN Cervical Overview Group
Dec 3, 2010·The Journal of Rheumatology·Pierre LangevinUNKNOWN Cervical Overview Group

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