PMID: 3766147Jul 1, 1986Paper

The analgesic effect of buprenorphine, etorphine and pethidine in the pig: a randomized double blind cross-over study

Acta Pharmacologica Et Toxicologica
K HermansenH O Olesen

Abstract

In order to find a suitable analgesic for the treatment of postoperative pain in pigs the analgesic effect of buprenorphine, etorphine and pethidine has been compared in 8 domestic pigs. For assessment of the analgesic action on thermal (hot plate) and two mechanical (cannulation of ear vein, needle prick) noxious stimuli have been employed. In a pilot experiment on 2 pigs in which methadone was included the maximal effective doses were estimated for each drug. Methadone was found unsuitable because of unacceptable side effects (respiratory dysfunction, hyperactivity) at effective dose levels. Next buprenorphine 120 micrograms/kg, etorphine 3 micrograms/kg and pethidine 20 mg/kg all given intramuscularly were compared in a randomized blind trial with a balanced cross-over design on 6 pigs. Etorphine proved to have the highest and pethidine the lowest maximal analgesic effect which was especially evident in the needle-prick test. Buprenorphine proved to have the longest duration of action in all three analgesic tests, in the hot plate test lasting between 7 and 24 hrs. Etorphine had a duration of 3 to 5 hrs whereas the effect of pethidine was short, only lasting about 2 hrs. Etorphine provides a complete analgesia but has a smal...Continue Reading

References

Jan 1, 1979·British Journal of Clinical Pharmacology·M J Rance
Aug 1, 1977·British Journal of Pharmacology·A CowanI R Macfarlane
Aug 1, 1977·British Journal of Pharmacology·A CowanE J Harry
Sep 29, 1973·The Veterinary Record·J E CoxR Ewbank
Apr 1, 1984·Laboratory Animals·P A Flecknell

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Citations

Sep 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·A E WatermanA Amin
Jul 4, 2019·Animals : an Open Access Journal From MDPI·Joost UilenreefEllen Meijer
Oct 26, 2018·BMC Veterinary Research·Abbie V Viscardi, Patricia V Turner

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