The analgesic effects of buprenorphine (Vetergesic or Simbadol) in cats undergoing dental extractions: A randomized, blinded, clinical trial

PloS One
Ryota WatanabePaulo Steagall

Abstract

This study aimed to evaluate the analgesic efficacy of two dosage regimens using two different concentrations of buprenorphine in cats undergoing dental extractions. Twenty-three cats with oral disease (8.2 ± 2.2 years old; 4.9 ± 0.9 kg) were included in a prospective, blinded, randomized clinical trial. Cats randomly received either Simbadol (1.8 mg/mL; 0.24 mg/kg, subcutaneously, every 24h: SG, n = 11) or Vetergesic (0.3 mg/mL; 0.02 mg/kg, intramuscularly, every 8h: VG, n = 12) throughout the study. They were admitted at day 0, underwent oral examination/radiographs/treatment under general anesthesia (buprenorphine-propofol-isoflurane-meloxicam-local anesthetic blocks) at day 1 and discharged at day 4. Sedation and pain were scored using the dynamic interactive visual analog scale (day 1) and the Glasgow Composite Measure Pain Scale-Feline (CMPS-F; up to postoperative 8 hours at day 1, 8 am, 4 pm and midnight at days 2 and 3, and 8 am at day 4), respectively. Rescue analgesia was administered with hydromorphone (0.05 mg/kg intravenously on day 1 or 0.1 mg/kg intramuscularly after day 2) when CMPS-F ≥ 5. Resentment defined as any type of escape behavior associated with aversion to drug administration was recorded. Sedation and...Continue Reading

References

Sep 7, 2007·The Journal of Small Animal Practice·M J DayUNKNOWN Vaccination Guidelines Group (VGG) of the World Small Animal Veterinary Association (WSAVA)
Sep 25, 2012·Veterinary Anaesthesia and Analgesia·Paulo V M SteagallPolly M Taylor
Mar 25, 2014·Journal of Veterinary Internal Medicine·P V M SteagallP M Taylor
Oct 16, 2015·Journal of Feline Medicine and Surgery·Javier BenitoPaulo V Steagall
Dec 3, 2016·Journal of Veterinary Pharmacology and Therapeutics·B T Simon, P V Steagall
Oct 16, 2018·Journal of Feline Medicine and Surgery·Paulo V Steagall, Beatriz P Monteiro
Feb 19, 2019·Journal of the American Animal Hospital Association·Jan BellowsAndrea G Van de Wetering

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